The occurrence of knee osteoarthritis(KOA)is closely related to kidney deficiency and marrow decrease.When kidney defi-ciency and marrow decrease leads to the onset of KOA,it will cause the lack of cerebral nourishment,leading to the dysfunction of the brain spirit.So kidney deficiency and marrow decrease is the fundamental etiology and pathogenesis for the occurrence of KOA and dys-function of the brain spirit.KOA tends to occur in middle-aged and elderly people.In the course of its development,the kidney deficien-cy and marrow decrease are more severe,which leads to the dysfunction of the brain spirit,and then Central sensitization(CS)occurs.CS is one of the important mechanisms for the development and maintenance of pain in KOA.The pain abnormalities,emotional disor-ders,cognitive disorders,and sleep disorders induced by CS are actually the abnormal regulation of human mental activity and conscious thinking by the brain in TCM after dysfunction of the brain spirit.Improving dysfunction of the brain spirit,and inhibiting CS can allevi-ate abnormal pain and hyperalgesia in KOA patients,and improve other accompanying symptoms such as cognitive impairment,anxiety,and depression,etc.Bone stiffness is the main manifestation of KO A,and CS caused by dysfunction of the brain spirit is an extension of the development process of KOA.This provides a theoretical basis for TCM to intervene KOA by inhibiting CS,thereby improving knee joint pain and dysfunction.It is conducive to understanding the pathogenesis of CS from a holistic perspective,identifying potential tar-gets of CS through syndrome differentiation,and providing new ideas and strategies for inhibiting CS to improve knee joint pain and dys-function in KOA patients.
关键词
膝骨关节炎/脑神失养/脑/中枢敏化/肾虚髓减
Key words
knee osteoarthritis(KOA)/dysfunction of the brain spirit/brain/central sensitization/kidney deficiency and marrow de-crease
维普
万方数据