Clinical Study on Modified Bupleurum and Scutellaria Purgative Decoction Combined with Acupuncture in the Treatment of Severe Acute Pancreatitis
Objective:To observe the effect of Modified Bupleurum and Scutellaria Purgative Decoction combined with acupuncture on immune function,inflammatory response and nutritional status in patients with severe acute pancreatitis.Methods:A total of 60 patients with severe acute pancreatitis were divided into the conventional group and the experimental group according to the random number ta-ble method,with 30 cases in each group.The conventional group was treated with Modified Bupleurum and Scutellaria Purgative Decoc-tion,while the experimental group was treated with Modified Bupleurum and Scutellaria Purgative Decoction combined with acupunc-ture.The changes in the immune function indexes,inflammatory factor levels[including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C reactive protein(CRP)],nutritional status,TCM syndrome scores and intestinal mucosal barrier function indexes before and after treatment were compared between the two groups.Results:After treatment,the levels of CD3+,CD4+,CD4+/CD8+ in the two groups were lower than those before treatment,while CD8+ was higher than that before treatment,and all the differences between the two groups were statistically significant(P<0.05);the levels of IL-6,TNF-α and CRP in the two groups were lower than those before treat-ment,and the above indexes in the experimental group were lower than those in the conventional group(P<0.05);the levels of albu-min and hemoglobin in the two groups were higher than those before treatment,and the above indexes in the experimental group were higher than those in the conventional group(P<0.05);the syndrome scores of TCM in the two groups were lower than those before treatment,and the above indexes in the experimental group were lower than those in the conventional group(P<0.05);the contents of D-lactic acid and diamine oxidase in the two groups were lower than those before treatment,and the above indexes in the experimental group were lower than those in the conventional group(P<0.05).Conclusion:Modified Bupleurum and Scutellaria Purgative Decoction combined with acupuncture in the treatment of patients with severe acute pancreatitis can improve the clinical symptoms,enhance the immune function and nutritional status,and reduce the level of inflammatory factors.
severe acute pancreatitisModified Bupleurum and Scutellaria Purgative Decoctionacupuncture therapyimmune functioninflammatory responsenutritional status
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