目的:探讨独活寄生汤联合电针疗法对膝骨关节炎(knee osteoarthritis,KOA)患者膝关节功能、炎性因子水平及骨代谢指标的影响.方法:将62 例KOA患者采用随机抽签法分为对照组和联合组,每组各31 例.对照组给予电针疗法,联合组在对照组治疗的基础上联合独活寄生汤.比较两组患者的临床疗效及治疗前后视觉模拟疼痛评分(visual analogue scale,VAS)、膝骨关节炎指数(the western ontario and mcmaster universities,WOMAC)、炎性因子水平[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、转化生长因子-β(transforming growth factor-β,TGF-β)]、骨代谢指标(骨钙素、Ⅰ型胶原C端肽)变化情况.结果:联合组有效率为96.77%,高于对照组的77.42%,差异有统计学意义(P<0.05).两组患者治疗后VAS评分低于本组治疗前、WOMAC评分高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).两组患者治疗后TNF-α、IL-1β、TGF-β低于本组治疗前,且治疗后联合组低于对照组(P<0.05).两组患者治疗后骨钙素高于治疗前,Ⅰ型胶原 C端肽低于本组治疗前(P<0.05),且治疗后组间比较,差异具有统计学意义(P<0.05).结论:独活寄生汤联合电针治疗KOA,可改善患者的临床症状,促进关节功能恢复,抑制炎性因子水平,提高骨代谢能力.
Clinical Study on Pubescent Angelica and Mistletoe Decoction Combined with Electro-acupuncture in the Treatment of Knee Osteoarthritis
Objective:To study the effects of Pubescent Angelica and Mistletoe Decoction combined with electro-acupuncture therapy on knee function,inflammatory factors and bone metabolism indexes in patients with knee osteoarthritis(KOA).Methods:A total of 62 pa-tients with KOA were randomly divided into the control group and the combined group,with 31 cases in each group.The control group was given electro-acupuncture therapy,while the combined group was given electro-acupuncture therapy combined with Pubescent An-gelica and Mistletoe Decoction.The clinical efficacy and the changes in visual analogue scale(VAS),the western ontario and mcmaster universities osteoarthritis index(WOMAC),inflammatory factors levels[including tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),transforming growth factor-β(TGF-β)]and bone metabolism indexes(including osteocalcin,type I collagen C telopeptide)before and after treatment were compared between the two groups.Results:The effective rate of the combined group was 96.77%,which was higher than that of the control group(77.42%),and the difference was statistically significant(P<0.05).After treatment,the VAS score of the two groups was lower than that before treatment,while the WOMAC score was higher than that before treatment,and the differences between the two groups were statistically significant(P<0.05);the TNF-α,IL-1β,and TGF-β of the two groups were lower than those before treatment,and the combined group's above indexes were lower than those of the control group(P<0.05);the osteocalcin of the two groups was higher than that before treatment,while the C-telopeptide of type I collagen was lower than that before treatment(P<0.05),and all the differences between the two groups were statistically significant(P<0.05).Conclusion:Pubescent Angelica and Mistletoe Decoction combined with electroacupuncture in the treatment of KOA can improve the clinical symptoms of pa-tients,promote the recovery of joint function,inhibit the level of inflammatory factors,and enhance bone metabolism.
knee osteoarthritis(KOA)Pubescent Angelica and Mistletoe Decoctionelectro-acupuncture therapy
万方数据
维普
