Research Progress of Regulation of PI3K/AKT Signaling Pathway with Yin-Restoring Pill
Yin-Restoring Pill is a representative formula for nourishing yin and tonifying the kidney,which has the effects of nourishing yin and enriching marrow,warming and strengthening kidney yang,and filling the essence and tonifying the kidney.Modern research has shown that it mainly plays a preventive and curative role in the prevention and treatment of neurological,reproductive,endocrine and or-thopedic diseases by regulating related cytokines in the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB,also known as AKT)signaling pathway.The main mechanism is to regulate the downstream target proteins such as B-cell lymphoma-2(Bcl-2),BCL2-Associated X(Bax),cysteinyl aspartate-specific proteinase-3(Caspase-3),glycogen synthase kinase3β(GSK3β),mammalian target of rapamycin(mTOR),and forkhead box O(FOXO)by phosphorylating AKT at different sites,which plays a biological preventive and curative role in regulating cell cycle,promoting cell metabolism,growth and proliferation,inhibiting apoptosis,regulating oxidative stress and inflammatory response,regulating energy metabolism,and regulating tumor cell formation.Although Yin-Restoring Pill has been widely used in clinical practice,its pharmacological effects and molecular mechanisms on the prevention and treatment of related disea-ses have not been precisely defined.In the future,deep research on the molecular biology of Yin-Restoring Pill in the prevention and treatment of diseases is needed to further clarify the potential clinical application value.
Yin-Restoring Pillphosphatidylinositol-3-kinase(PI3K)/proteinkinase B(PKB)signal pathwaynourishing yin and enric-hing the marrowwarming and strengthening kidney yangfilling the essence and tonifying the kidney
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