Study on the Correlation Between TCM Syndromes of IgA Nephropathy and Urinary Protein Electrophoresis and Urine-Retinolbinding Protein and Urine-Immunoglobulin G
Objective:To study the correlation between TCM syndromes of IgA nephropathy and urinary protein electrophoresis and urine-retinolbinding protein(U-RBP)and urine-immunoglobulin G(U-IgG).Methods:A total of 120 patients with IgA nephropathy hospital-ized in the Department of Nephrology,Jiujiang Hospital of Traditional Chinese Medicine from April 2021 to May 2022 were selected.Ac-cording to their symptoms,the syndrome types were determined,the general information of patients with each syndrome type was collect-ed,and the serum creatinine(Scr)level of patients with each syndrome type was detected.Fresh morning urine was collected before re-nal biopsy,and the urinary protein detection rate,U-RBP and U-IgG levels were determined.Results:Among 120 patients with IgA ne-phropathy,qi-yin deficiency syndrome accounted for the highest proportion(28.33%),followed by liver-kidney yin deficiency syn-drome,spleen-kidney qi deficiency syndrome,lung-kidney qi deficiency syndrome,and spleen-kidney yang deficiency syndrome,ac-counting for 24.17%,18.33%,15.83%,and 13.33%,respectively.There were significant differences in the course of disease among patients with different syndrome types of IgA nephropathy(P<0.05).After SDS-AGE electrophoresis analysis of urine from 120 pa-tients with IgA nephropathy,93 cases were positive for proteinuria.The probability of glomerular proteinuria in qi-yin deficiency syn-drome and liver-kidney yin deficiency syndrome was higher than that in other syndrome types,and the probability of mixed proteinuria in spleen-kidney yang deficiency syndrome was higher than that in lung-kidney qi deficiency syndrome and spleen-kidney qi deficiency syndrome(P<0.05).There were significant differences in the levels of Scr,U-RBP,and U-IgG among patients with different syndrome types of IgA nephropathy(P<0.05),and the levels of serum Scr,U-RBP,and U-IgG in patients with spleen-kidney qi deficiency syn-drome or lung-kidney qi deficiency syndrome were significantly lower than those in other three syndrome types(P<0.05).In terms of the LEE classification,the proportion of lung-kidney qi deficiency syndrome at grade I was higher than that of liver-kidney yin deficiency syndrome and spleen-kidney yang deficiency syndrome,and the proportion of grade IV was lower than that of liver-kidney yin deficiency syndrome.In terms of the LEE classification of spleen-kidney qi deficiency syndrome,the proportion of grade I was higher than that of liver-kidney yin deficiency syndrome and spleen-kidney yang deficiency syndrome,and the proportion of grade IV was lower than that of qi-yin deficiency syndrome and liver-kidney yin deficiency.And all the differences were statistically significant(P<0.05).Conclu-sion:The detection rate of glomerular and mixed proteinuria,U-RBP and U-IgG levels in patients with IgA nephropathy are related to TCM syndromes.Comprehensive analysis of their correlations can provide reference for TCM syndrome differentiation of IgA nephropathy to some extent.
IgA nephropathyurinary protein electrophoresisurine-retinolbinding protein(U-RBP)urine-immunoglobulin G(U-IgG)qi-yin deficiency syndromeliver-kidney yin deficiency syndromespleen-kidney qi deficiency syndromelung-kidney qi deficiency syn-dromesplee
万方数据
维普
