Clinical Study on Qi-Replenishing and Detoxification Decoction in the Treatment of Primary Liver Cancer
Objective:To observe the clinical efficacy of Qi-Replenishing and Detoxification Decoction on primary liver cancer and its in-fluence on the expression of hypoxia inducible factor-1α(HIF-1α)and related cytokines in patients'serum.Methods:A total of 80 pa-tients with primary liver cancer were divided into the control group and the experimental group according to the random number table method,with 40 cases in each group.The control group was given apatinib mesylate for oral treatment,while the experimental group was given Qi-Replenishing and Detoxification Decoction on the basis of the control group.The levels of serum HIF-1α,endothelial growth factor(VEGF),matrix metalloproteinase(MMP)-2,and MMP-9 in the two groups were quantitatively detected by ELISA before treat-ment and after 8 weeks of treatment respectively,and the clinical efficacy and incidence of adverse reactions in the two groups were compared.Results:The remission rate of the experimental group was 37.5%,which was higher than that of the control group:20%,and the difference was statistically significant(P<0.05).After treatment,the levels of MMP-2,MMP-9,VEGF,and HIF-1αin the two groups were lower than those before treatment,while the levels of MMP-2 and HIF-1α in the experimental group were lower than those in the control group,and all the differences were statistically significant(P<0.05).The incidence of hypertension and fatigue in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05),but there was no statistically significant difference in the incidence of rash,hand-foot syndrome,fever,diarrhea,and proteinuria between the two groups(P>0.05).Conclusion:Qi-Replenishing and Detoxification Decoction for the treatment of primary liver cancer can relieve the clinical efficacy of patients,reduce the levels of HIF-1α and MMP-2,and inhibit tumor angiogenesis.
primary liver cancerQi-Replenishing and Detoxification Decoctionapatinib mesylateintegrated traditional Chinese and Western medicine therapyhypoxia-inducible factor-1αendothelial growth factormatrix metalloproteinase-2matrix metalloproteinase-9
国家科技期刊平台
NSTL
万方数据
维普
