A Meta-analysis of Licorice and Wheat and Jujube Decoction for Treating Malignant Cancer-Related Depression
Objective:To systematically review the clinical efficacy of Licorice and Wheat and Jujube Decoction in treating cancer-related depression.Methods:The computer was used to search databases such as China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Database,China Biomedical Literature Database,PubMed,Cochrane Library,and Web of Science to collect randomized con-trolled clinical trials on Licorice and Wheat and Jujube Decoction for treating cancer-related depression from the establishment of the database to June 30,2023,and a Meta-analysis was conducted using Review Manager 5.4.1 software.Results:A total of 10 articles were included in this review,involving a total of 739 patients,with 370 in the observation group and 369 in the control group.The Meta-analy-sis showed that the effective rate in the observation group was higher than that in the control group after treatment with Licorice and Wheat and Jujube Decoction[OR=1.91,95％CI(1.07,3.40),P=0.03].The HAMD score in the observation group was lower than that in the control group[MD=-8.17,95％CI(-13.12,-3.22),P=0.001].The SDS score in the observation group was lower than that in the control group,and the difference was statistically significant[MD=-17.45,95％CI(-23.18,-11.72,P＜0.000 01].The level of CD3+in the observation group was higher than that in the control group[MD=9.85,95％CI(8.75,10.94),P＜0.000 01].The level of CD4+in the observation group was higher than that in the control group[MD=5.85,95％CI(3.14,8.56),P＜0.000 1].The level of CD8+in the observation group was lower than that in the control group[MD=-4.82,95％CI(-6.45,-3.18),P＜0.000 01].In terms of CD4+/CD8+,there was no significant difference between the observation group and the control group(MD=0.31,95％CI(-0.12,0.75),P=0.16);the NK level in the observation group was higher than that in the con-trol group(MD=34.26,95％CI(20.52,47.99),P＜0.000 1);the quality of life score in the observation group was higher than that in the control group(MD=12.14,95％CI(10.76,13.51),P＜0.000 1).Conclusion:Licorice and Wheat and Jujube Decoction has significant therapeutic effects in treating cancer-related depression,which can improve the patients'depressive state,enhance immune function and quality of life.
cancer-related depressionLicorice and Wheat and Jujube DecoctionMeta-analysisSynopsis of the Golden ChamberZhang Zhongjing
国家科技期刊平台
NSTL
万方数据
