目的:观察温肺化饮汤治疗儿童变应性鼻炎致慢性湿性咳嗽临床疗效及安全性,并探讨其作用机制.方法:选取2019年12月至2022年3月在广东省中西医结合医院就诊的患儿70例,随机分为对照组和治疗组,每组各35例.对照组采用孟鲁司特钠、氯雷他定、糠酸莫米松鼻喷雾剂治疗,治疗组在对照组治疗基础上加用中药温肺化饮汤治疗.两组均以14 d为1个疗程,1个疗程后判定疗效,观察两组患儿治疗前后咳嗽积分、症状评分、生活量表评分及血清总免疫球蛋白E(immunoglobulin E,IgE)、呼出一氧化氮(the fraction of exhaled nitric oxide,FeNO)水平.结果:对照组优良率为71.87％,治疗组优良率为90.90％,两组优良率比较,差异有统计学意义(P＜0.05).两组患儿治疗后咳嗽积分、VAS评分、症状评分、生活质量评分均较治疗前下降,差异有统计学意义(P＜0.05),且组间比较,差异有统计学意义(P＜0.05).两组患儿治疗后IgE和FeNO水平均较治疗前下降,差异有统计学意义(P＜0.05),且组间比较,差异有统计学意义(P＜0.05).结论:温肺化饮汤可改善变应性鼻炎致慢性湿性咳嗽患儿临床症状,其作用机制可能与降低血清IgE和气道FeNO水平有关.
Clinical Research on the Treatment of Chronic Damp Cough in Children with Allergic Rhinitis by Decoction for Warming Lung and Resolving Retained Fluid
Objective:To observe the clinical efficacy and safety of Decoction for Warming Lung and Resolving Retained Fluid in the treatment of chronic damp cough caused by allergic rhinitis(AR)in children,and to explore its effective mechanism.Methods:A total of 70 children who were admitted to Guangdong Province Hospital of Traditional Chinese& Western Medicine from December 2019 to March 2022 were selected and randomly divided into the control group and the treatment group,with 35 cases in each group.The control group was treated with montelukast sodium,cetirizine hydrochloride,and budesonide nasal spray,while the treatment group was treated with Decoction for Warming Lung and Resolving Retained Fluid on the basis of the control group's treatment.Both groups had a 14-day treatment course,and the efficacy was evaluated after one course.The cough symptom score,symptom score,quality of life scale score,and serum total immunoglobulin E(IgE)and fraction of exhaled nitric oxide(FeNO)levels of the two groups were observed before and after treatment.Results:The results showed that the excellent rate in the control group was 71.87％,while that in the treatment group was 90.90％.There was a statistically significant difference between the two groups(P＜0.05).After treatment,the cough score,VAS,symptom score,and quality of life score of both groups were lower than those before treatment,and the differences were statistically sig-nificant(P＜0.05).There was a statistically significant difference between the two groups(P＜0.05).The levels of IgE and FeNO in both groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).There was a statistical-ly significant difference between the two groups(P＜0.05).Conclusion:Decoction for Warming Lung and Resolving Retained Fluid can improve the symptoms of chronic damp cough in children with AR,and its mechanism of action may be related to reducing serum IgE and airway FeNO levels.
allergic rhinitis(AR)in childrenchronic damp coughDecoction for Warming Lung and Resolving Retained Fluid
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