Research Progress of TCM for Regulating Intestinal Microbiota in the Treatment of Gastric Cancer with Depression Based on the Theory of Brain-Gut Axis
In a physiological state,the brain and intestines are interconnected and mutually nourishing.In pathological conditions,the brain and intestines interact with each other,promoting the occurrence and development of diseases.TCM can treat gastric cancer with depression by regulating intestinal microbiota,and its mechanism of action may be through regulating brain gut peptide levels and intes-tinal microbiota.Common treatment methods of gastric caner with depression include single medicine and its high-purity extract,Chinese medicinal compound formulas,acupuncture and moxibustion,acupoint application,acupoint moxibustion,combination of acupuncture and medicine,etc.,all of which have achieved good efficacy,but the current research still has the following shortcomings:(1)The cur-rent animal models used to explore the efficacy of TCM in treating gastric cancer are mostly based on a single disease model,fail to fully integrate the unique concept of TCM syndrome differentiation and treatment,which may limit the comprehensive understanding of biolog-ical changes related to gastric cancer.(2)There is a lack of in-depth research on the material basis of Chinese medicinal compound for-mulas and monomer components,and the internal connections between various pharmacological effects,as well as the specific contribu-tions and coordination mechanisms of monomer components in the mechanism,are not clear.In the future,it is necessary to develop modern animal models that combine the characteristics of diseases and syndromes,which can more accurately reflect clinical practice and meet the technological needs of modern TCM research.In addition,it is necessary to establish stricter quality control standards for Chinese medicinals,deepen the research on the material basis of Chinese medicinal compound formulas and monomer components,and clarify various medicine-efficacy relationships.
gastric cancer with depressionthe theory of brain-gut axisintestinal microbiota
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