Research Progress on Oxidative Stress and Infertility
In physiological conditions,the small amount of reactive oxygen species produced by the body plays an important role in fe-male reproductive processes(such as the development and maturation of follicles,ovulation,the activity of the corpus luteum,and em-bryo implantation,etc.)through different signal transduction pathways.In pathological conditions,excessive reactive oxygen species can trigger oxidative stress,leading to metabolic dysfunction,mitochondrial dysfunction,inflammatory responses,and ultimately,the onset of disease.There is a certain correlation between oxidative stress and various reproductive endocrine disorders such as luteal phase defect,endometriosis,and unexplained infertility.Both Western medicine and TCM can achieve satisfactory therapeutic effects by using antioxi-dant therapy to treat infertility.Currently,although the use of antioxidants can effectively alleviate oxidative stress,there is still no com-prehensive understanding of its dosage,administration time,etc.More clinical research is needed.Secondly,the complex components of Chinese medicinal compounds make it necessary to continuously deepen the exploration of their mechanisms of action,which can provide supportive evidence for the study of oxidative stress in female infertility and the safety of drug use.In addition,human health status and lifestyle are also considered to be important factors affecting oxidative stress.Therefore,in addition to receiving antioxidant treatment,it is also advisable to establish a regular lifestyle and engage in appropriate exercise,which will help the body to exert its antioxidant function.
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