Research Progress in TCM Regulation Mechanism of Neurogenic Bladder in Patients with Spinal Cord Injury
After spinal cord injury(SCI),neurogenic bladder(NB)disease is located in the bladder,and the basic pathogenesis can be summarized as deficiency of kidney yang,inability to transform qi into water,and the principle that"without yang,yin cannot be trans-formed",leading to urinary failure;or due to the scorching heat of the lower energizer,which does not heal over time and consumes body fluids,leading to deficiency of kidney yin,depletion of the water chamber,and ultimately resulting in ischuria.Acupuncture,moxibus-tion,Chinese medicinals,massage and other methods have been widely used in the treatment of NB after SCI.Acupuncture,moxibus-tion,etc.mainly focus on local acupoint selection,with the highest frequency of acupoint selection in the conception vessel,followed by Guanyuan(RN 4),Zhongji(RN 3),Ciliao(BL 32),etc.The research on the regulation mechanism of TCM therapy on NB after SCI mainly focuses on promoting functional recovery of spinal cord damaged segments(including inhibiting spinal cord cell apoptosis,reduc-ing neuronal inflammatory response),improving bladder function(such as enhancing bladder muscle contraction function,improving bladder nerve innervation,reducing bladder tissue cell apoptosis),and controlling neurotransmitter expression.At present,some relevant clinical literature lacks the concept of NB syndrome differentiation and treatment,which may lead to insufficient rigor and comparability of the articles,and the efficacy evaluation is mostly immediate,lacking long-term follow-ups.Some experimental research mechanisms are relatively single,lacking large-scale,multi-channel,and high-quality research.Stem cell therapy has received increasing atten-tion due to its ability to directly rescue damaged spinal cord.Stem cell differentiation and its paracrine effects are the mechanisms that enhance SCI recovery.The use of mesenchymal stem cells and neural stem cells can improve bladder function.Whether TCM therapy can regulate the proliferation and differentiation of spinal cord neural stem cells,promote nerve repair in the injured area,and thus re-store bladder function requires further research in the future.
neurogenic bladder(NB)spinal cord injury(SCI)TCM regulation mechanismbladder function
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