Clinical Study on the Treatment of Non-alcoholic Fatty Liver Disease with Dampness-Heat Accumulation Syndrome with Kuhuang Granules
Objective:To observe the clinical efficacy of Kuhuang Granules on non-alcoholic fatty liver disease(NAFLD)with damp-heat accumulation syndrome.Methods:A total of 62 NAFLD patients were randomly divided into the control group and the treatment group,with 31 cases in each group.The control group received polyene phosphatidylcholine treatment,while the treatment group re-ceived Kuhuang Granules in addition to the control group's treatment.The controlled attenuation parameter(CAP)and liver stiffness measurement(LSM)were measured before and after treatment in both groups.The changes in TCM syndrome scores,blood lipids[in-cluding high density lipoprotein cholesterol(HDL),triacylglycerol(TG),total cholesterol(TC)],and liver function[including ala-nine transaminase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(GGT)]were compared before and after treat-ment.The clinical efficacy,quantitative liver fat efficacy,and liver fat efficacy measured by abdominal ultrasound were compared be-tween the two groups.Results:(1)Quantitative liver fat efficacy:The effective rate of the treatment group was 95.00%,which was sig-nificantly higher than 84.00%of the control group,with a statistically significant difference(P<0.05).(2)Liver fat efficacy meas-ured by abdominal ultrasound:The effective rate of the treatment group was 93.50%,which was higher than 77.40%of the control group,with a statistically significant difference(P<0.05).(3)Clinical efficacy:The effective rate of the treatment group was 90.32%,which was higher than61.29%of the control group,with a statistically significant difference(P<0.05).(4)After treat-ment,the CAP values in both groups were lower than those before treatment,and the treatment group had lower values than the control group(P<0.05).(5)After treatment,AST,ALT,and GGT in both groups were lower than those before treatment,and the treatment group had lower values than the control group(P<0.05).(6)After treatment,TC in both groups was lower than that before treatment,and the treatment group had lower values than the control group,with a statistically significant difference(P<0.05);there were no sta-tistically significant differences in TG and HDL between the two groups(P>0.05).(7)After treatment,LSM values in both groups were lower than those before treatment,with a statistically significant difference(P<0.01),but there was no statistically significant difference between the groups after treatment(P>0.05).(8)After treatment,there were statistically significant differences in symp-toms such as general heaviness,abdominal distension or pain,sticky stools,jaundice,and dry mouth and bitter taste between the two groups(P<0.05).Conclusion:Kuhuang Granules can reduce liver fat content,improve liver function,lower blood lipid levels,and ef-fectively alleviate clinical symptoms in the treatment of NAFLD with dampness-heat accumulation syndrome.
non-alcoholic fatty liver disease(NAFLD)dampness-heat accumulation syndromeKuhuang Granulespolyene phosphati-dylcholineintegrated traditional Chinese and Western medicine therapy
万方数据
维普
