The mechanisms of the method of tonifying the kidney and activating blood in treating repeated planting failure(RIF)in-clude:(1)Adjusting natural killer(NK)cells and related factors in RIF patients to modulate the immune system bidirectionally,pro-moting the growth of trophoblast cells,implantation of the fertilized egg,placental vascular formation,and embryo implantation;(2)re-ducing tumor necrosis factor-α in RIF patients,adjusting the dynamic balance of Th1/Th2 cytokines,and protecting the embryo;(3)improving the uterine endometrial microenvironment,increasing endometrial thickness,enhancing endometrial receptivity,creating an optimal environment for implantation of the fertilized egg,and improving embryo implantation rates;(4)regulating hemorheological indi-cators,reducing blood viscosity,increasing uterine blood perfusion,regulating microcirculation,improving the pre-thrombotic state,effec-tively reducing the high resistance state of uterine artery blood flow in RIF patients,and aiding successful embryo implantation;(5)co-ordinating the functions of kidney qi,tiangui,thorough vessel,conception vessel,and uterus,improving reproductive endocrine levels,in-creasing the number and quality of oocytes,enhancing ovarian reserve function in patients with in vitro fertilization-embryo transfer(IVF-ET)failure,and improving the pregnancy outcomes of RIF patients.At present,although clinical research on the method of tonify-ing the kidney and activating blood is becoming more abundant,there are still significant limitations in theoretical discussion and mecha-nism research on RIF,lacking experimental data and large sample support.In the future,it is necessary to increase large sample,multi-center research and conduct relevant experimental studies as much as possible to fully leverage the advantages of Chinese medicine in infertility,aiming to improve the success rate of IVF-ET.
repeated implantation failure(RIF)method of tonifying the kidney and activating bloodin vitro fertilization-embryo trans-ferovarian reserve function
维普
万方数据
