Study on Regulating Colorectal Cancer Tumor Microenvironment with Spleen-Invigorating and Phlegm-Resolving Method Based on Lipid Metabolism Reprogramming
Both phlegm and lipids originate from the transformation of body fluids from grains.Phlegm is a pathogenic factor,while lipids are physiological components.Abnormal distribution of body fluids leads to the accumulation of phlegm and abnormal lipid metabolism,disrupting the body's internal environment of yin and yang balance,creating a microenvironment conducive to tumor growth,and thus leading to cancer formation.Lipid metabolism disorder is a typical feature of colorectal cancer,and abnormal blood lipids can also affect the tumor microenvironment,leading to immune suppression.The spleen is the source of the biochemical transformation of qi and blood,governing transportation and transformation.When spleen's function is impaired,abnormal transportation and transformation of body flu-ids occur.Invigorating the spleen and resolving phlegm can correct abnormal fluid distribution,facilitating the movement of accumulated phlegm.When lipid metabolism disorder occurs without tumors,strengthening the spleen and resolving phlegm can promptly correct the lipid disorder.After tumor formation,this method can prevent the further development of the"phlegm environment,"regulate the tumor microenvironment of colorectal cancer,inhibit the mutation of normal cells and the growth and proliferation of tumor cells,reprogram lip-id metabolism in the tumor microenvironment,and restore the body's internal environment of yin and yang balance.The spleen is closely related to the body's immune function,so invigorating the spleen and regulating the stomach can modulate immunity,thereby exerting anti-tumor effects.
lipid metabolism reprogrammingspleen-invigorating and phlegm-resolving methodcolorectal cancertumor microenviron-ment
万方数据
维普
