Clinical Study on Qi-Replenishing and Heart-Dredging Decoction Combined with Dapagliflozin in the Treatment of Heart Failure with Reduced Ejection Fraction
Objective:To observe the clinical efficacy of Qi-Replenishing and Heart-Dredging Decoction combined with Dapagliflozin on heart failure with reduced ejection fraction(HFrEF).Methods:A total of 120 HFrEF patients were randomly divided into the control group and the observation group,with 60 cases in each group.The control group was given Dapagliflozin,while the observation group was given a combination of Qi-Replenishing and Heart-Dredging Decoction and Dapagliflozin.The clinical efficacy,incidence of adverse re-actions,and changes in TCM syndrome scores before and after treatment were compared between the two groups.The levels of inflamma-tory factors[including hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),lipo-protein associated phospholipase 2(Lp-PLA2)],and cardiac function indicators[including serum N-terminal brain natriuretic peptide precursor(NT-proBNP),growth stimulation expressed gene 2(ST2),and left ventricular ejection fraction(LVEF)]were detected.Results:After treatment,hs-CRP,IL-6、TNF-α,Lp-PLA2 and TCM syndrome scores were lower than those before treatment in each group,and the observation group's above indicators were lower than those of the control group(P<0.05).The levels of NT-pro BNP and ST2 in the two groups were lower than those before treatment,while the level of LVEF was higher than that before treatment.All the differences between the two groups were statistically significant(P<0.05).The effective rate of the observation group was86.67%,while that of the control group was70.00%,with a statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclu-sion:The combination of Qi-Replenishing and Heart-Dredging Decoction and Dapagliflozin in the treatment of heart failure with reduced ejection fraction can alleviate clinical symptoms,reduce inflammatory factor levels,improve cardiac function indicators,and enhance clinical efficacy without significant adverse reactions.
heart failure reduced ejection fractionQi-Replenishing and Heart-Dredging DecoctionDapagliflozinintegrated traditional Chinese and Western medicine therapy
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