A Meta-Analysis of the Xiakucao Herbal Preparations on Hashimoto's Thyroiditis
Objective:To evaluate the clinical efficacy of Xiakucao(Spica Prunellae)herbal preparations on Hashimoto's thyroiditis(HT)and provide evidence-based medical support for its widespread clinical application.Methods:This study conducted a comprehen-sive search of domestic and international literature databases,including Wanfang Data,China National Knowledge Infrastructure,Si-noMed,VIP Chinese Journal Service Platform,and international databases,such as Embase,PubMed,Web of Science,and Cochrane.The search was limited to the databases'inception until July 2023.The inclusion criteria were clinical randomized controlled trials using Xiakucao herbal preparations to treat HT.The quality of the literature was assessed using the bias risk assessment standard recommen-ded by Cochrane Collaboration Network in RevMan 5.4 software,and a Meta-analysis of treatment efficacy,serum TSH,TPO-Ab,TG-Ab levels,and TCM syndrome scores was conducted using the same software.The safety of the treatment was also evaluated.Results:A total of 5 770 Chinese-language articles were retrieved,and no foreign-language articles specifically using Xiakucao for HT were found.Final-ly,16 articles involving 1 170 subjects were included,with 592 cases in the treatment group and 578 cases in the control group.Four ar-ticles used Xiakucao herbal preparations alone,and 12 articles combined Xiakucao herbal preparations with control group's treatments.The Meta-analysis showed that the treatment group significantly outperformed the control group in improving the clinical efficacy rate for HT patients[RR=1.29,95％CI(1.21,1.37),Z=7.85,P＜0.000 01];reducing TSH levels[MD=-0.72,95％CI(-1.54,0.10),Z=1.73,P=0.08],TG-Ab levels[MD=-45.03,95％CI(-49.59,-40.48),Z=19.39,P＜0.000 01],and TPO-Ab antibody titers[MD=-71.85,95％CI(-90.28,-53.42),Z=7.64,P＜0.000 01];and significantly reducing TCM syndrome scores[MD=-3.24,95％CI(-4.48,-2.00),Z=5.11,P＜0.000 01].Conclusion:Xiakucao herbal preparations,either combined with Western medicine or used alone,can significantly improve the clinical efficacy of treating HT,reduce TSH,TG-Ab,and TPO-Ab antibody titers,lower TCM syndrome scores,and have good safety.
万方数据
维普
