Clinical Observation of Spleen-Invigorating and Blood-Activating and Kidney-Tonifying Decoction in the Treatment of Rheumatoid Arthritis with Spleen-Kidney Deficiency and Phlegm-Blood Stasis Blocking Collaterals Syndrome in the Elderly
Objective:To observe the effect of Spleen-Invigorating and Blood-Activating and Kidney-Tonifying Decoction on interleukin(IL)-6,serum amyloid A(SA A),and tumor necrosis factor(TNF)-α in elderly patients with rheumatoid arthritis(RA)of the spleen-kidney deficiency and phlegm-blood stasis blocking collaterals syndrome type.Methods:A total of 80 RA patients with spleen-kidney de-ficiency and phlegm-blood stasis blocking collaterals syndrome treated at Xinyu Hospital of Traditional Chinese Medicine between De-cember 2021 and December 2023 were selected,and randomly divided into the control group and the observation group,with 40 cases in each group.The control group received Methotrexate Tablets,Folic Acid Tablets,and Celecoxib Capsules for oral administration,while the observation group was additionally treated with Spleen-Invigorating and Blood-Activating and Kidney-Tonifying Decoction.The chan-ges in TCM syndrome scores,quality of life scores,RA-related indicators[including rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(CCP-AB),erythrocyte sedimentation rate(ESR)],and inflammatory cytokines(including IL-6,SAA,and TNF-α)before and after treatment were observed in both groups.Results:After treatment,the TCM syndrome scores such as joint pain,joint swelling,difficulty in joint flexion and extension,and morning stiffness,etc.were significantly lower in the observation group than those in the control group,and the differences were statistically significant(P＜0.05);The quality of life scores in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05);RF,CCP-AB,and ESR levels were significantly lower in the observation group than those in the control group,and the differences were statistically significant(P＜0.05).Additionally,IL-6,SAA,and TNF-α levels were significantly reduced in the observation group compared to the control group,and the differences were statistically significant(P＜0.05).Conclusion:Spleen-Invigorating and Blood-Activating and Kidney-Tonifying Decoction can alleviate the symptoms of RA in elderly patients with spleen-kidney deficiency and phlegm-blood stasis bloc-king collaterals syndrome,reduce IL-6,SAA,and TNF-α levels,and improve the patients'quality of life.
rheumatoid arthritis(RA)in the elderlySpleen-Invigorating and Blood-Activating and Kidney-Tonifying Decoctioninter-leukin-6serum amyloid A(SAA)tumor necrosis factor-α(TNF-α)spleen-kidney deficiency and phlegm-blood stasis blocking col-laterals syndrom
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维普
