首页|八正散加减治疗湿热下注型反复发作性尿路感染临床研究

八正散加减治疗湿热下注型反复发作性尿路感染临床研究

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目的:观察八正散治疗湿热下注型反复发作性尿路感染(recurrent urinary tract infection,RUTI)的临床疗效.方法:将80例湿热下注型RUTI患者按照随机数字表法分为对照组和试验组,每组各40例.试验组给予八正散加减治疗,对照组给予左氧氟沙星片治疗.比较两组患者的临床疗效、复发情况、不良反应发生情况及治疗前后中医证候积分、血清指标[白细胞计数、C反应蛋白(C reactive protein,CRP)和降钙素原(procalcitonin,PCT)]、尿常规(白细胞计数、细菌计数)变化情况.结果:试验组有效率为100.00%,对照组有效率为72.50%,两组患者有效率比较,差异具有统计学意义(P<0.05).两组患者治疗后主症和次症积分低于本组治疗前,且治疗后试验组低于对照组(P<0.05).两组患者治疗后血清白细胞计数、CRP、降钙素原水平低于本组治疗前,治疗后试验组血清白细胞计数、降钙素原水平低于对照组(P<0.05),治疗后两组CRP水平比较,差异无统计学意义(P>0.05).两组患者治疗后尿液中白细胞计数及细菌计数低于本组治疗前,差异具有统计学意义(P<0.05),但两组治疗后白细胞计数及细菌计数比较,差异无统计学意义(P>0.05).试验组在6个月随访中复发次数少于对照组(P<0.05);试验组复发率为27.50%,低于对照组的62.50%,差异具有统计学意义(P<0.05).结论:八正散治疗湿热下注型RUTI临床疗效确切,能有效改善中医证候,降低血清炎性指标、尿常规指标及复发率.
Clinical Study on Modified Eight-Ingredient Rectification Powder in the Treatment of Recurrent Urinary Tract Infection with Syndrome of Down-Pouring Dampness-Heat
Objective:To observe the clinical efficacy of Eight-Ingredient Rectification Powder on recurrent urinary tract infection(RU-TI)with syndrome of down-pouring dampness-heat.Methods:A total of 80 RUTI patients with syndrome of down-pouring dampness-heat were randomly divided into the control group and the experimental group,with 40 cases in each group.The experimental group received Modified Eight-Ingredient Rectification Powder for treatment,while the control group was treated with Levofloxacin Tablets.The clinical efficacy,recurrence rates,adverse reactions,and changes in TCM syndrome scores,as well as serum indicators[including white blood cell count,C-reactive protein(CRP),and procalcitonin(PCT)]and urine routine tests[including white blood cell count and bacterial count)]before and after treatment were compared between the two groups.Results:The effective rate in the experimental group was 100.00%,and 72.50%in the control group,with a statistically significant difference(P<0.05).After treatment,the scores for prima-ry and secondary symptoms in both groups were lower than those before treatment,with the experimental group scoring lower than those of the control group(P<0.05).Serum white blood cell count,CRP,and PCT levels were significantly lower than those before treatment in both groups,and the experimental group's white blood cell count and PCT levels were lower than those of the control group(P<0.05).Urinary white blood cell count and bacterial count were significantly lower than those before treatment in both groups(P<0.05),but there were no significant differences in white blood cell count and bacterial count between the two groups(P>0.05).Dur-ing the 6-month follow-up,the average recurrence frequency in the experimental group was less than that in the control group(P<0.05),with a recurrence rate of 27.50%in the experimental group compared to 62.50%in the control group,showing a significant difference(P<0.05).Conclusion:Eight-Ingredient Rectification Powder is effective in treating RUTI patients with syndrome of down-pouring dampness-heat,and can significantly improve TCM syndrome scores,reduce serum inflammatory indicators,urine routine indica-tors,and recurrence rates.

recurrent urinary tract infection(RUTI)syndrome of down-pouring dampness-heatEight-Ingredient Rectification PowderLevofloxacin

张鹏

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荥阳市中医院,河南荥阳 450100

反复发作性尿路感染 湿热下注证 八正散 左氧氟沙星

2024

河南中医
河南省中医药学会 河南中医学院

河南中医

影响因子:0.968
ISSN:1003-5028
年,卷(期):2024.44(11)