Research Progress in Active Components of Chinese Medicinals for Regulating Apoptosis to Prevent and Treat Cervical Cancer
Active components of Chinese medicinals inhibit the growth and proliferation of cervical cancer cells by regulating apoptosis through mitochondrial pathways,endoplasmic reticulum pathways,and a combination of multiple pathways.This provides a theoretical foundation for the application of Chinese medicinals in the treatment of cervical cancer and offers potential directions for further research and development of new anti-tumor therapies.However,there are still some problems as follows:(1)Most studies focus on in vitro ex-periments at the cellular level,with a lack of clinical research on cervical cancer treatment;(2)While intervention in the mitochondrial pathway is the most common mechanism through which active components of Chinese medicinals regulate apoptosis,these components often affect multiple apoptotic pathways,and research on the complex regulatory mechanisms remains to be enriched;(3)There is little explicit discussion of signaling pathways in the prevention and treatment of cervical cancer,with the PI3K/AKT signaling pathway men-tioned sporadically,making it difficult to conduct in-depth studies as a common pathway.Therefore,well-designed clinical trials and ani-mal experiments should be further developed for promising active components of Chinese medicinals to evaluate their efficacy and safe-ty.Future research should integrate systems biology,artificial intelligence,data mining technologies,and other interdisciplinary knowl-edge to explore and analyze the regulatory mechanisms of active components of Chinese medicinals,clarifying the targets and signaling pathways involved in their apoptotic and anti-cancer effects.
cervical canceractive components of Chinese medicinalsmitochondriaendoplasmic reticulumdeath ligandautophagyap-optosis
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