The Clinical Reasoning for Major Purgative Decoction for Treating Stroke-Associated Pneumonia
Major Purgative Decoction,originating from Zhang Zhongjing's Treatise on Cold Damage Diseases,is a representative formula for purgative method,primarily used to treat yang brightness organ excess,interior heat excess syndrome,and heat accumulation binding with fluid retention.Clinically,it is often applied in cases of acute abdominal diseases,intestinal obstruction,and gastrointestinal dys-function,while also demonstrating therapeutic efficacy in stroke-associated pneumonia(SAP).In treating SAP,Major Purgative Decoc-tion is guided by the principle of"interior-exterior relationship between the lung and large intestine."Rather than directly targeting the lung,this approach focuses on unblocking and descending bowel qi to clear pulmonary toxins,thereby showing the unity of disease differ-entiation and syndrome differentiation in TCM.Furthermore,distinguishing primary and secondary factors and assessing urgency is cruci-al in managing complex,severe conditions,as treatment requires precise judgment and timely intervention.In the future,further clinical research and practice are needed to fully explore the therapeutic potential and mechanisms of Major Purgative Decoction,offering safer and more effective options for SAP treatment.
stroke-associated pneumonia(SAP)Major Purgative Decoctionpurgative methodTreatise on Cold Damage DiseasesZhang Zhongjing
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