加味三子汤治疗痰瘀阻肺型慢性阻塞性肺疾病急性加重期临床研究
Clinical Study on Supplemented Three-Seed Decoction in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Syndrome of Phlegm-Stasis Blocking the Lung
刘治 1朱小明 1陈永明 1丁程香1
作者信息
- 1. 兴国县结核病防治所,江西 兴国 342400
- 折叠
摘要
目的:观察加味三子汤治疗痰瘀阻肺型慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床疗效及其对患者临床症状及血气指标的影响.方法:将 92 例痰瘀阻肺型AECOPD患者按照随机数字表法分为对照组和观察组,每组各46 例.对照组给予常规西医治疗,观察组在对照组治疗的基础上给予加味三子汤治疗.比较两组患者的临床疗效及治疗前后中医证候积分、炎性因子水平[白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α、TNF-α)、C反应蛋白(C reactive protein,CPR)]、血气指标[动脉血氧分压(arterial oxygen partial pressure,PaO2)、动脉血二氧化碳分压(arterial carbon dioxide pressure,PaCO2)、动脉血氧饱和度(arterial oxygen saturation,SaO2)水平、pH值]及呼吸困难程度.结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组(P<0.05).对照组有效率为76.09%,观察组有效率为93.48%,两组患者有效率比较,差异具有统计学意义(P<0.05).两组患者治疗后IL-6、TNF-α、CRP水平低于本组治疗前,且治疗后观察组低于对照组(P<0.05).两组患者治疗后PaCO2 低于本组治疗前,PaO2、SaO2、pH高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).两组患者治疗后CAT评分低于本组治疗前,且治疗后观察组低于对照组(P<0.05).结论:加味三子汤治疗痰瘀阻肺型AECOPD,可提高临床疗效,降低炎性因子水平,改善临床症状、血气指标及呼吸困难程度.
Abstract
Objective:To observe the clinical efficacy of Supplemented Three-Seed Decoction on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with syndrome of phlegm-stasis blocking the lung,and its effects on patients' clinical symptoms and blood-qi indexes.Methods:A total of 92 patients with phlegm-stasis lung-blocking type AECOPD were randomly divided into the control group and the observation group,with 46 cases in each group.The control group received conventional Western medicine treatment,while the observation group was treated with Supplemented Three-Seed Decoction in addition to the conventional treatment.Clinical effi-cacy,TCM syndrome scores,inflammatory markers[including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive pro-tein(CRP)],blood-qi indexes[including arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2),arterial oxygen saturation(SaO2),pH],and dyspnea levels before and after treatment were compared between the two groups.Results:After treatment,the TCM syndrome scores of both groups were lower than those before treatment,and the observation group had signifi-cantly lower scores than those of the control group(P<0.05).The effective rate in the control group was 76.09%,while that in the observation group was 93.48%,with a statistically significant difference(P<0.05).The levels of IL-6,TNF-α,and CRP were lower than those before treatment,and the observation group had significantly lower levels than those of the control group(P<0.05).PaCO2 was lower than that before treatment,while PaO2,SaO2,and pH were higher than those before treatment,and all the differences between the groups were statistically significant(P<0.05).The CAT scores after treatment were lower than those before treatment,with the ob-servation group showing significantly lower scores than the control group(P<0.05).Conclusion:Supplemented Three-Seed Decoction can improve the clinical efficacy in treating phlegm-stasis lung-blocking type AECOPD,reduce inflammatory markers,and improve clini-cal symptoms,blood-qi indexes,and the degree of dyspnea.
关键词
慢性阻塞性肺疾病/痰瘀阻肺证/加味三子汤/中西医结合疗法Key words
chronic obstructive pulmonary disease(AECOPD)/syndrome of phlegm-stasis blocking the lung/Supplemented Three-Seed Decoction/integrated traditional Chinese and Western medicine引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据