Clinical Study on the Efficacy of Astragalus and Colla Corii Asini Capsules for Increasing White Blood Cells Combined with Recombinant Human Granulocyte Colony Stimulating Factor in Treating Chemotherapy-Induced Leukopenia with Qi-Blood Deficiency Syndrome
Objective:To observe the clinical efficacy of Astragalus and Colla Corii Asini Capsules for Increasing White Blood Cells com-bined with recombinant human granulocyte colony stimulating factor(rhG-CSF)on chemotherapy-induced leukopenia with qi-blood de-ficiency syndrome.Methods:A total of 128 patients with chronic renal failure combined with renal anemia treated at Xinyu Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were selected.They were randomly divided into the control group and the test group,with 64 cases in each group.When the peripheral blood white blood cell count(WBC)was<4.0×109 L-1 after chemo-therapy,the control group received rhG-CSF injection within 24 hours after chemotherapy,while the test group received Astragalus and Colla Corii Asini Capsules for Increasing White Blood Cells orally in addition to rhG-CSF.The changes in CD3+,CD8+,CD4+,CD4+/CD8+,high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF)-α,interleukin(IL)-6,WBC,hemoglobin(Hb),platelet count(PLT),infection frequency,antibiotic usage time,rhG-CSF dosage and duration,clinical efficacy,and adverse reactions were observed in both groups before and after treatment.Results:After treatment,CD3+,CD8+,CD4+,CD4+/CD8+increased in both groups,with the test group showing significantly higher levels than those of the control group,and the differences were statistically signif-icant(P<0.05).TNF-α,IL-6 and hs-CRP levels decreased in both groups,and the test group had significantly lower levels than those of the control group,and the differences were statistically significant(P<0.05).The test group had lower infection rates,antibiotic us-age time,rhG-CSF dosage,and duration compared to the control group,and the differences were statistically significant(P<0.05).The clinical efficacy rate was 81.25％in the test group and 71.88％in the control group respectively,with the test group showing a signifi-cantly higher efficacy rate,and the difference was statistically significant(P<0.05).Adverse reactions occurred in 15 cases(23.44％)in the control group and 6 cases(9.38％)in the test group,with the test group showing a significantly lower adverse reaction rate,and the differences was statistically significant(P<0.05).Conclusion:Astragalus and Colla Corii Asini Capsules for Increasing White Blood Cells combined with rhG-CSF can increase white blood cell levels in patients with chemotherapy-induced leukopenia with qi-blood deficiency syndrome,correct blood system disorders,reduce inflammation,and decrease the incidence of adverse reactions.
chemotherapy-induced leukopeniaAstragalus and Colla Corii Asini Capsules for Increasing White Blood Cellsrecombinant human granulocyte colony stimulating factor(rhG-CSF)qi-blood deficiency syndromewhite blood cellT lymphocytes
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