参芪地黄汤配合沙库巴曲缬沙坦钠片治疗糖尿病肾病临床研究
Clinical Study on the Treatment of Diabetic Nephropathy with Ginseng and Astragalus and Rehmannia Decoction Combined with Sacubitril Valsartan Sodium Tablets
康豪鹏 1徐晓妍2
作者信息
- 1. 河南电力医院,河南 郑州 450052
- 2. 河南中医药大学第一附属医院,河南 郑州 450001
- 折叠
摘要
目的:观察参芪地黄汤配合沙库巴曲缬沙坦钠片治疗糖尿病肾病(diabetic nephropathy,DN)的临床疗效.方法:选取2022 年1 月至2023 年6 月河南电力医院收治的DN患者102 例,按照随机数字表法分为对照组和观察组,每组 51 例.对照组给予常规治疗,观察组在对照组治疗的基础上给予参芪地黄汤治疗.观察两组患者治疗前后中医证候总积分、空腹血糖(fasting blood glucose,FBG)、餐后2h血糖(2 h postprandial blood glucose,2hPBG)、血清胱抑素(cystain C,Cys-c)、视黄醇结合蛋白(retinol binding protein,RBP)水平及临床疗效、不良反应发生情况.结果:观察组有效率为 86.27%,对照组有效率为68.63%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后中医证候总积分低于对照组,差异有统计学意义(P<0.05);观察组治疗后FBG、2hPBG水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后Cys-c、RBP水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:参芪地黄汤联合沙库巴曲缬沙坦钠片治疗糖尿病肾病,可提高临床疗效,缓解中医证候,有效调节血糖水平,改善肾功能.
Abstract
Objective:To observe the clinical efficacy of Ginseng and Astragalus and Rehmannia Decoction combined with Sacubitril Val-sartan Sodium Tablets on diabetic nephropathy(DN).Methods:A total of 102 DN patients admitted to Henan Electric Power Hospital between January 2022 and June 2023 were selected and randomly divided into the control group and the observation group,with 51 ca-ses in each group.The control group received conventional treatment,while the observation group was additionally treated with Ginseng and Astragalus and Rehmannia Decoction.The changes in total TCM symptom scores,fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PBG),serum cystatin C(Cys-C),and retinol binding protein(RBP)levels,as well as clinical efficacy and adverse reactions before and after treatment were observed.Results:The effective rate of the observation group was 86.27％,significantly higher than 68.63％in the control group,with a statistical difference(P<0.05).After treatment,the total TCM symptom scores in the obser-vation group were lower than those of the control group,with a significant difference(P<0.05);FBG and 2 h PBG levels in the obser-vation group were significantly lower than those in the control group,with statistical differences(P<0.05);Serum Cys-C and RBP lev-els in the observation group were lower than those in the control group,with statistical significances(P<0.05).However,no significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Gin-seng and Astragalus and Rehmannia Decoction and Sacubitril Valsartan Sodium Tablets can improve the clinical efficacy in the treat-ment of DN,alleviate TCM symptoms,effectively regulate blood glucose levels,and improve renal function.
关键词
糖尿病肾病/参芪地黄汤/沙库巴曲缬沙坦钠片/血糖/肾功能/中西医结合疗法Key words
diabetic nephropathy(DN)/Ginseng and Astragalus and Rehmannia Decoction/Sacubitril Valsartan Sodium Tablets/blood glucose/renal function/integrated traditional Chinese and Western medince therapy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据