Overview of Research on TCM Syndrome Elements and Syndrome Typing in Coronary Heart Disease
Coronary atherosclerotic heart disease(commonly referred to as coronary heart disease)has a primary pathological mecha-nism of coronary obstruction,with a fundamental pathology of"root deficiency with branch excess."Key TCM syndrome elements in-clude latent toxins,wind pathogens,blood stasis,phlegm-dampness,cold pathogens,qi stagnation,qi deficiency,yin deficiency,blood de-ficiency,and yang deficiency,etc.Research on coronary heart disease syndrome typing based on metabolomics offers a clearer under-standing of therapeutic mechanisms and elucidates the multi-pathway,multi-target approach characteristic of TCM treatment.Proteomics-based research aids in exploring the micro-material basis of different syndromes,while genomics provides insight into the genetic founda-tion of syndrome differentiation.However,most current research focuses on phlegm-dampness and blood stasis syndromes,with limited research on other syndrome types.In the future,it is essential to strengthen foundational research on syndrome typing and biological un-derpinnings in coronary heart disease to provide objective evidence for clinical diagnosis and treatment.Furthermore,exploring the corre-lation between TCM pathology and modern pathophysiological mechanisms,along with identifying biological foundations of syndrome typ-ing,can facilitate early prevention strategies,reveal new treatment targets,and enhance treatment effectiveness for coronary heart dis-ease.
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