Research Progress in the Mechanisms of Glycoside Compounds of Chinese Medicinals in the Prevention and Treatment of Bone Nonunion Bone
The mechanisms by which glycoside compounds of Chinese medicinals treat bone nonunion include promoting osteoblast dif-ferentiation,inhibiting osteoclast formation,enhancing angiogenesis,and reducing inflammatory responses,etc.These compounds achieve multiple therapeutic objectives through multi-pathway,multi-target,and multi-efficacy strategies to promote bone formation and inhibit bone destruction,etc.However,current research faces limitations,such as insufficient depth in mechanistic studies,lack of large-scale clinical trials,inadequate drug delivery systems,lack of consideration for individual variability,and unclear long-term side effects.Future studies should focus on in-depth exploration of molecular mechanisms,clinical trials to validate efficacy and safety,improvements in drug delivery systems,personalized treatments,evaluation of long-term side effects,and potential integration with other therapies.These efforts may open new strategies and perspectives for clinical treatment of bone nonunion.
glycoside compounds of Chinese medicinalsfracturebone nonunionosteoblast
国家科技期刊平台
NSTL
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