The Expression of Th17 Cells Activation and Proliferation Related Factors in Peripheral Blood of Patients with Blood-heat Syndrome of Psoriasis Vulgaris
Objective To explore the role of Th17 cell activation and proliferation related factors in the pathogenesis of psoriasis vulgaris of blood-heat syndrome and material foundation as well as dialectical basis of blood-heat syndrome of psoriasis vulgaris.Methods 12 patients with blood-heat syndrome of psoriasis vulgaris were enrolled from our hospital dermatology clinic,and 11 cases of healthy individuals as normal control.The expression level of Th17 cells activation related factor HLA-DR,proliferation factor Ki-67 in peripheral blood of patients with blood-heat syndrome of psoriasis vulgaris and healthy subjects were examined by multicolor flow cytometry.Results Thelevel of Th17 cells activated factor HLA-DR in peripheral blood of patients was high expression compared with control group (11.686％± 4.799％ vs 8.016％± 2.334％,P＜0.05),the expression of proliferation factor Ki-67 was also increased compared to control group (8.727％± 3.854％ vs 5.665％± 2.251％,P＜0.05).But the activation factor HLA-DR,proliferation factor Ki-67 and psoriasis area and severity index (PASI) score did not show correlations (r1=0.021,r2=0.098,P＞0.05).Conclusion The high expression of Thl7 cell activation factor HLA-DR and proliferation factor Ki-67 in peripheral blood of patients with psoriasis of blood-heat syndrome,indicates theperipheral blood of patients with psoriasis of blood-heat syndrome-Th17 cells were at a high state of activation and proliferation.Both HLA-DR and Ki-67 may indirectly involved in the pathogenesis process of psoriasis of blood-heat syndrome.They are probably novel material foundations and dialectical basis of blood-heat syndrome of psoriasis.
国家科技期刊平台
NSTL
万方数据
维普
