Objective To observe the effect of Danzhi Xiaoyao Powder (DZXYP) on the expression of androgen, leptin and leptin receptor (LEPR) in polycentric ovary (PCO) hyperandrogenism rats. Methods The PCO Hyperandrogenism model rats induced by dehydroepiandrosterone (DHEA) were randomly divided into DZXYP group, Diane group, model group and blank control group. The morphologic changes were observed after the experiment. The levels of androgen were determined by radio-immunity. Serum leptin was determined by ELISA. LEPR in the tissues of ovaries was assessed with immunohistochem-istry method. Results Danzhi Xiaoyao Powder could reduce the values of leptin, testosterone, free testosterone, and the expres-sion of LEPR obviously, the differences were statistically significant (P<0.01). Conclusion DZXYP could reduce the levels of leptin, androgen and decrease the expression of LEPR of PCO hyperandrogenism rats. Then it could decrease the bioavailabili-ty of leptin and androgenic activities to improve high serum-T and ovulation barrier of polycentric ovary syndrome.
国家科技期刊平台
NSTL
万方数据
维普
