Formulation rules of TCM compound formulas for high-risk human papilloma virus infection based on data mining
Objective To explore the formulation rules in the TCM treatment of high-risk human papilloma virus(HR-HPV)infection.Methods TCM compound formulas for treating HR-HPV infection that met the inclusion and exclusion criteria were collected from CNKI,VIP Database,and Wanfang Database until July10,2023.Softwares such as Excel 2007,Cytoscape 3.9.1,Rstudio 4.3.2,and R 4.3.2 were used for data modeling,pattern analysis,medication frequency analysis,cluster analysis,association rule analysis,and data visualization,so as to investigate the formulation rules for treating HR-HPV infection.Results A total of 231 compound formulas for treating persistent HR-HPV infection were included,involving 225 Chinese medicines,with a total medication frequency of 2450.The most common clinical patterns were spleen deficiency and liver qi stagnation pattern(39.39%)and damp heat downflow pattern(37.67%).The top 10 frequently used Chinese medicines were Huangbo(Phellodendri Chinensis Cortex),Baizhu(Atractylodis Macrocephalae Rhizome),Huangqi(Astragali Radix),Tufuling(Smilacis Glabrae Rhizome),Baihuasheshecao(Hedyotis Diffusa),Gancao(Glycyrrhizae Radix et Rhizome),Yiyiren(Coicis Semen),Dangshen(Codonopsis Radix),Kushen(Sophorae Flavescentis Radix),and Cangzhu(Atractylodis Rhizome).As to the categories of medicinal effects,the top three were heat clearing(38.98%),deficiency tonifying(23.10%),and urination-promoting and dampness-draining(10.24%)categories.Cluster analysis identified seven combinations of Chinese medicines,including two novel formulas available for clinical use and new drug development and three medicine pairs.The core complex co-occurrence network identified the core Chinese medicines of Huangqi(Astragali Radix)-Baizhu(Atractylodis Macrocephalae Rhizoma)-Huangbo(Phellodendri Chinensis Cortex).Association rule analysis yielded 37 medicinal combinations(6 paired combinations and 31 triple combinations).The commonly used paired medicines were Baizhu(Atractylodis Macrocrphalae Rhizoma)-Dangshen(Codonopsis Radix),Huangqi(Astragali Radix)-Dangshen(Codonopsis Radix),Huangbo(Phellodendri Chinensis Cortex)-Cangzhu(Atractylodis Rhizome),etc.The commonly used triple medicinal combinations were Baizhu(Atractylodis Macrocrphalae Rhizoma)-Dangshen(Codonopsis Radix)-Huangqi(Astragali Radix),Baizhu(Atractylodis Macrocrphalae)-Huangqi(Astragali Radix)-Tufuling(Smilacis Glabrae Rhizoma),Huangbo(Phellodendri Chinensis Cortex)-Baihuasheshecao(Hedyotis Diffusa)-Yiyiren(Coicis Semen),etc.Conclusion The basic pathogenesis of HR-HPV is spleen deficiency,liver qi stagnation,and damp heat downflow,and the disease nature is deficiency in root and excess in manifestation.Accordingly,Chinese medicines such as Baizhu(Atractylodis Macrocrphalae),Huangqi(Astragali Radix),and Dangshen(Codonopsis Radix)have been mostly used in the formulas to tonify qi of the spleen and stomach,so as to benefit the deficiency and prevent pathogenic factors from impenetrating;meanwhile,they have been combined with heat-clearing and dampness-drying medicines such as Tufuling(Smilacis Glabrae Rhizoma),Huangbo(Phellodendri Chinensis Cortex),and Baihuasheshecao(Hedyotis Diffusa)to relieve the manifestations,which is consistent with clinical medication.To sum up,the fundamental compound formulas and medicinal combinations have been obtained through multidimensional data mining and statistical analysis,which can provide reference for clinical treatment of HR-HPV infection and new drug development.
国家科技期刊平台
NSTL
万方数据
维普
