Research progress on cisplatin resistance mechanisms in nasopharyngeal carcinoma
Nasopharyngeal carcinoma(NPC)is one of the common malignant tumors in clinic.Currently,chemotherapy with cisplatin as the representative drug and radiotherapy are the main treatment options for NPC,but the high chemoresistance could pose significant challenges.The mechanisms of cisplatin resistance in NPC can be summarized into six aspects,namely increasing intracellular drug concentration,reducing cisplatin inactivation,enhancing DNA damage and inhibiting damage repair,promoting apoptosis,regulating tumor microenvironment,and inhibiting intracellular autophagy.Hence,this paper briefly reviews the research progress on cisplatin resistance in NPC cells,aiming to offer research directions for reversing cisplatin resistance in NPC and finding natural,safe,and effective chemotherapeutic sensitizers.
nasopharyngeal carcinomacisplatinresistance mechanismapoptosisreversing drug resistanceanti-oxida-tive stressresearch progress
国家科技期刊平台
NSTL
万方数据
维普
