摘要
鼻咽癌是临床上常见的恶性肿瘤之一.以顺铂为代表药物的化学药物治疗和放射治疗是目前治疗鼻咽癌的主要手段.多发的肿瘤化疗药物耐药现象为鼻咽癌的治疗带来极大困扰.鼻咽癌顺铂耐药机制可以概括为6个方向:增加细胞内药物浓度、减少顺铂的失活物质、增加DNA损伤和抑制损伤修复、促进细胞凋亡、调节肿瘤微环境、抑制胞内自噬.对鼻咽癌细胞在顺铂的耐药性中的研究进展作简要综述,为逆转鼻咽癌顺铂耐药以及寻找天然、安全、有效的化学药物治疗增敏剂的研究提供方向.
Abstract
Nasopharyngeal carcinoma(NPC)is one of the common malignant tumors in clinic.Currently,chemotherapy with cisplatin as the representative drug and radiotherapy are the main treatment options for NPC,but the high chemoresistance could pose significant challenges.The mechanisms of cisplatin resistance in NPC can be summarized into six aspects,namely increasing intracellular drug concentration,reducing cisplatin inactivation,enhancing DNA damage and inhibiting damage repair,promoting apoptosis,regulating tumor microenvironment,and inhibiting intracellular autophagy.Hence,this paper briefly reviews the research progress on cisplatin resistance in NPC cells,aiming to offer research directions for reversing cisplatin resistance in NPC and finding natural,safe,and effective chemotherapeutic sensitizers.
基金项目
湖南省中医耳鼻喉临床医学研究中心项目(2020SK4024)
湖南省研究生科研创新项目(2023)(CX20230798)
国家科技期刊平台
NSTL
维普
万方数据