Chemical constituents of ethyl acetate extracts of the culture solution of Hericium erinaceus
Objective To study the chemical constituents of ethyl acetate extracts of the culture solution of H e ric ium erinaceus.Methods Compounds were isolated and purified using Sephadex LH-20 column chromatography,silica gel column chromatography,semi-preparative HPLC and so on,and their structures were identified based on their physicochemical properties and spectral data.Results A total of 22 compounds were isolated and obtained from the ethyl acetate extracts of the culture solution of Hericium erinaceus,including 3-methoxy-4-hydroxybenzaldehyde(1),methyl indole-3-carboxylate(2),2-furancarboxylic acid(3),benzoic acid(4),2(3H)-benzoxazolone(5),vanillic acid(6),gallic acid(7),polisin C(8),bis(2-ethylhexyl)benzene-1,2-dicarb-oxylate(9),p-tyrosyl acetate(4-hydroxyphenethyl acetate)(10),1-(4-hydroxy-3,5-dimethoxyphenyl)ethanon(11),hydroxyacetophenone(12),1-phenyl-1,2-propanediol(13),6-hydroxy isobenzofuran-1(3H)-one(14),4-hydroxyphenylacetaldehyde(15),1H-indole-3-carbox-aldehyde(16),cyclo(Pro-Val)(17),cyclo(Pro-Leu)(18),cyclo(Phe-Val)(19),cyclo(Ile-Phe)(20),3',5'-dimethoxy-4',5,7-trihydroxyflavone(21),and dihydro-4-hydroxy-2(3H)-furanone(22).Conclusion With the exception of compounds 16 and 21,all other compounds were isolated from the culture solution of Hericium erinaceus for the first time.
culture solution of Hericium erinaceuschemical constituentssmall-molecular compoundscyclopeptidesal-kaloids
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