Medication rules of blood-circulating and blood stasis-eliminating method in treating restenosis after percutaneous coronary intervention based on data mining and holistic concept
Objective To explore the medication rules of blood-circulating and blood stasis-eliminating method in treating restenosis after percutaneous coronary intervention(PCI).Methods Relevant literature in the Chinese and English databases was searched,and TCM formulas that met the criterion were included,by which an original database was established.Microsoft Excel 2021,IBM SPSS Modeler 18.0,Cytoscape 3.9.1,and IBM SPSS Statistics 26.0 were applied to the analyses of high-frequently used Chinese medicines,and their effects,indications,properties,flavors,and meridian affinity,as well as to the association rule and hierarchical cluster analyses,so as to summarize the medication rules.Results A total of 73 articles and 73 TCM formulas were included,involving 125 Chinese medicines.High-frequently used Chinese medicines included Danshen(Salviae Miltiorrhizae Radix et Rhizoma),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),Danggui(Angelicae Sinensis Radix),Chishao(Paeoniae Radix Rubra),Honghua(Carthami Flos),etc.Medicines with effects of circulating blood and eliminating blood stasis were the most,followed by those with the effect of tonifying deficiency.Most of the involved medicines were warm and cold in nature,and bitter,sweet,and pungent in flavor,entering the liver and spleen meridians.Association rule analysis yielded 3 medicine pairs,with the highest support in the pair of Honghua(Carthami Flos)-Taoren(Persicae Semen),and 26 triple combinations of medicines,mainly composed of Chuanxiong(Chuanxiong Rhizoma),Chishao(Paeoniae Radix Rubra),Honghua(Carthami Flos),Danggui(Angelicae Sinensis Radix),Huangqi(Astragali Radix),Taoren(Persicae Semen),etc.Five medicine combinations were obtained through hierarchical cluster analysis.Conclusion The basic pathogenesis of restenosis after PCI involves deficiency of heart qi and inactivity of heart yang,and static blood is a key pathological factor throughout the whole course of the disease,with the disease locations involving the heart,liver,and spleen.Qi of the five zang organs irrigates each other.Therefore,guided by the concept of holism,the main treatment focuses on circulating blood and eliminating blood stasis,combined with regulating qi,transforming phlegm,and warming yang.Mostly applied formulas were derived from modified classic formulas such as Buyang Huanwu Decoction,Xuefu Zhuyu Decoction,Danggui Buxue Decoction,Gualou Xiebai Banxia Decoction,and Erchen Decoction.
万方数据
维普
