Guided by the theory of"kidney governing reproduction",the treatment of infertility in Chinese medicine mainly focuses on tonifying the kidney.Diminished ovarian reserve(DOR)is a common clinical disease leading to infertility.The incidence of DOR type infertility is increasing year by year and the age of onset tends to be younger.The kidney-tonifying method in Chinese medicine has unique advantages in treating DOR type infertility,the biological mechanism of which is mainly related to regulating the neuroendocrine functions of the hypothalamic-pituitary-ovarian axis,inhibiting abnormal programmed death of ovarian granulosa cells,adjusting abnormal immune functions,relieving excessive ovarian oxidative stress,improving the mitochondrial functions,regulating endometrial receptivity to improve ovarian functions,and thus enhancing fertility.This paper has summarized the biological mechanism of the kidney-tonifying method in Chinese medicine for DOR type infertility in recent years,providing new ideas for the clinical application of the"kidney governing reproduction"theory to the treatment of this disease.
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