Clinical efficacy of Shengfa Zhiyang Ointment in androgenic alopecia
Objective To investigate the clinical efficacy of Shengfa Zhiyang Ointment(SFZYO)in androgenic alopecia(AGA)and its effects on the expressions of serum interleukin-12(IL-12),interleukin-33(IL-33),and interferon-γ(IFN-γ).Methods Sixty AGA patients who attended the outpatient clinic of the dermatology department in Ningxiang Hospital of Chinese Medicine from August 2022 to May 2023 were selected and randomly divided into control group and observation group,with 30 cases in each group.The control group was treated with topical compound ketoconazole hair lotion,and the observation group with topical SFZYO.The treatment in each group was administered once every two days,for a total of 24 weeks.Standardized clinical photographs was taken,the subjective scores and the scalp oil scores were recorded;hair density and hair diameter were evaluated using the trichoscopic image analysis system;serum expression levels of IL-12,IL-33,and IFN-γ were measured by ELISA;Malassezia was detected in the scalp environment;routine examinations of blood and urine as well as liver and kidney function tests were carried out.Results After 12 and 24 weeks of treatment,the subjective scores by doctors in the observation group were higher than those in the control group(P<0.05),while the scalp oil scores by patients decreased significantly after 24 weeks compared with those of the control group(P<0.05);after 18 and 24 weeks of treatment,the hair diameter in the observation group was significantly larger than that in the control group(P<0.05),but the differences in hair density between the two groups at all time points were not statistically significant(P＞0.05).Compared with the control group,serum IL-12,IL-33,and IFN-γ levels were significantly reduced in the observation group after treatment(P<0.05),and the positive rate of scalp Malassezia was lower(P<0.05).There were no obvious abnormalities in the indicators of blood routine,urine routine and liver and kidney functions before and after treatment in both groups.Conclusion SFZYO has good efficacy and high safety in the clinical treatment of AGA.Its mechanism of action may be reducing the inflammatory response of the scalp and decreasing Malassezia,so as to alleviate the alopecia and promote hair regrowth,which is worthy of further popularization and application.
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