Theoretical exploration on relationship between oxytocin and the pathogenesis of autism spectrum disorder as well as intervention effects of tuina
Autism spectrum disorder(ASD),is a neurodevelopmental disorder that is mainly clinical manifestations by repetitive behaviors,impaired social interaction,and limited interests.As one of the commonly used therapies in pediatrics,tuina can significantly reduce the abnormal behaviors and improve the social abilities in children with ASD.In terms of basic research,the decrease of oxytocin(OXT)content is one of the important hypotheses for the pathogenesis of ASD,and the therapeutic effects of tuina may be related to the upregulation of OXT content through the activation of C-tactile afferent fibers by mechanical stimulation.This paper discusses the neurobiological mechanism of ASD pathogenesis from the perspective of OXT,and elucidates the potential connection between OXT and ASD pathogenesis,that is,the abnormal OXT can lead to the impairment of limbic reward system function in ASD patients,further inducing impaired social interaction.In addition,it discusses the specific mechanism of how tuina may produce therapeutic effects by regulating OXT content.
万方数据
维普
