Relationship between polypharmacokinetics and chromatopharmacokinetics of 11 components in Buyang Huanwu Decoction
Objective To elucidate the mathematical model and parameter relationship of the total statistical moment between polypharmacokinetics and chromatopharmacokinetics of the Chinese medicine compound formulas,to demonstrate the polypharmacokinetics and chromatopharmacokinetics study of 11 components in Buyang Huanwu Decoction(BYHWD),and to explore their dose-time relationship,including the metabolic time and chromatographic retention time.Methods HPLC/MS was used to determine the concentrations of 11 components such as astragaloside IV in BYHWD,and the polypharmacokinetic and chromatopharmacokinetic parameters were calculated based on the established total statistical moment mathematical model of Chinese medicine.Results The total moment parameters of polypharmacokinetics of AUCT,MRTT,VRTT,CLT,and VT of the 11 components in BYHWD were 432.9 ng·h·mL-1,2.185 h,5.259 h2,82.59 mL·h-1,and 139.9 mL respectively,and the 95%metabolic time interval was from 0 to 6.680 h.The total moment parameters of chromatopharmacokinetics of VUCT,MCRTT,and VCRTT were 457.5 ng·h·min·mL-1,5.625 min,and 7.949 min2 respectively,with a 95%time interval from 0.098 98 to 11.15 min.The RSD of the total zero,first,and second moments of chromatopharmacokinetics at each sampling time-point were 86.09%,2.299%,and 7.587%respectively,with the similarity basically above 0.875.Conclusion The total statistical moment method of polypharmacokinetics and chromatopharmacokinetics of Chinese medicine can represent the dose-time relationship of multi-component metabolism.Among them,the chromatopharmacokinetics can also represent the compositional changes and chromatographic characteristics of the measured metabolic components,laying a theoretical and experimental research foundation for clinical rational medication.
万方数据
维普
