The treatment of embedding eight acupoints around the umbilicus on obese polycystic ovary syndrome and its effects on androgen level and glucose-lipid metabolism
Objective To investigate the clinical effects of embedding eight acupoints around the umbilicus in the treatment of obese polycystic ovary syndrome(PCOS),and to explore the effects of embedding eight acupoints on androgen level and glucose-lipid metabolism in obese PCOS patients.Methods A total of 180 patients with obese PCOS and invitro fertilisation-embryotransfer(IVF-ET)treated in Cangzhou Hospital of Integrative Chinese and Western Medicine in Hebei Province from June 2019 to March 2023 were retrospectively analyzed.The patients were assigned into control group(n=48)and observation group(n=132)based on whether they received the treatment of embedding eight acupoints around the umbilicus.The single factor with significant differences were incorporated into the unconditional multivariate Logistic regression analysis model to analyze the independent influencing factors of effective treatment of obese PCOS with embedding eight acupoints around the umbilicus.Multivariate linear regression analysis was performed to explore the correlation between total cholesterol(TC),fasting insulin(FINS),homeostasis model assessment for insulin resistance(HOMA-IR),glycated hemoglobin(HbA1c),free androgen index(FAI),testosterone(T),and sex hormone-binding globulin(SHBG).Results Compared with those before treatment,fasting plasma glucose(FPG),FINS,HOMA-IR,HbAlc,2-hour plasma glucose concentration(2hPBG),TC,low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),waist-to-hip ratio(WHR),body mass index(BMI),luteinizing hormone(LH),LH/follicle-stimulating hormone(FSH),FAI,T,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were significantly reduced in both groups(P<0.05),while SHBG,high-density lipoprotein cholesterol(HDL-C),and FSH were significantly elevated(P<0.05).After treatment,compared with the control group,patients in the observation group had significantly lower levels of FINS,HOMA-IR,HbAlc,TC,TG,BMI,LH,LH/FSH,T,FAI,CRP,TNF-α,and IL-6(P<0.05),while SHBG was significantly higher(P<0.05).After treatment,the clinical pregnancy rate,live birth rate,and ovulation rate in the observation group were higher than those in the control group(P<0.05).The comparison of Chinese medicine pattern scores between the two groups revealed that the total scores,main pattern scores,and secondary pattern scores in both groups decreased significantly after treatment(P<0.05).Compared with the control group,the total scores,main pattern scores and secondary pattern scores in the observation group were lower after treatment(P<0.05).The effective rate of embedding eight acupoints around the umbilicus treatment was 92.42%,which was significantly higher than 83.33%of the control group(P<0.05).FAI exhibited a significant positive association with FINS,HOMA-IR,and HbA1c,whereas SHBG displayed a significant negative association with FINS,HOMA-IR,and HbA1c(P<0.05).T exhibited a significant positive association with TC and HOMA-IR(P<0.05).There were statistically significant differences in TC,FINS,HOMA-IR,and HbA1c levels among the four subgroups of FAI patients(P<0.05).The F3 and F4 groups exhibited significantly higher levels of TC,FINS,HOMA-IR,and HbA1c compared to the F1 and F2 groups(P<0.05).The F4 group exhibited significantly higher levels of TC and HbA1c compared to the F3 group(P<0.05).Conclusion The treatment of embedding eight acupoints around the umbilicus in obese PCOS patients can achieve better clinical efficacy,mainly through reducing FINS,FAI,HOMA-IR,T,TCM pattern scores,TC,IL-6,TNF-α,and HbA1c,as well as increasing SHBG levels.FAI and SHBG are influential factors of FINS,HOMA-IR,and HbA1c levels,while T is an influential factor in TC and HOMA-IR levels.The higher the level of FAI,the lower the level of glucose-lipid metabolism.
acupoint embeddingpolycystic ovary syndromeandrogen levelglucose-lipid metabolismeight acupoints around the umbilicusobesity
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