The relationship between irisin and the essence of heart yang deficiency pattern of chronic heart failure based on the theory of"movement generating yang"
The relationship between irisin and the essence of heart yang deficiency pattern of chronic heart failure based on the theory of"movement generating yang"
Chronic heart failure(CHF)is the end stage of heart disease caused by various factors,with heart yang deficiency being a key factor leading to its worsening.Irisin,an actin-glycosylated protein hormone,is a peptide cleavage product of fibronectin type Ⅲ domain containing 5(FNDC5)and is dependent on peroxisome proliferator-activated receptor γ coactivator-1α(PGC-1α),which presents in myocytes.During muscular movement,PGC-1α stimulates the expression of FNDC5,leading to increased release of irisin,which mediates the movement-related effects.The irisin produced in this process boosts mitochondrial capacity and promotes thermogenesis through adipose browning,thereby enhancing glucose metabolism and fatty acid oxidation.The theory of"movement generating yang"originates from the Yi Jing(Book of Changes),suggesting that"movement"is the source of the generation of yin and yang and thus of all things.For patients with heart yang deficiency pattern of CHF,exercise can revitalize their heart yang,promote the smooth circulation of qi and blood,alleviate CHF symptoms,and facilitate recovery.The essence of"movement generating yang"may be attributed to exercise mitigating the"qi deficiency"and"cold symptoms"in CHF patients with heart yang deficiency pattern,possibly through the regulation of energy metabolism and mitochondrial capacity by irisin produced during physical activity.Therefore,it is speculated that a deficiency of irisin may represent the biological essence of heart yang deficiency pattern of CHF.
关键词
动则生阳/鸢尾素/慢性心力衰竭/心阳虚证/能量代谢
Key words
movement generating yang/irisin/chronic heart failure/heart yang deficiency pattern/energy metabolism
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