首页|血管老化对心血管疾病的影响及中药干预机制

血管老化对心血管疾病的影响及中药干预机制

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血管老化是人体各器官、各系统衰老的重要病理基础,对高血压、动脉粥样硬化、心肌缺血再灌注损伤、冠心病等常见心血管疾病的发生产生重要影响.血管老化的病理机制主要为细胞衰老、氧化应激、线粒体功能障碍、慢性低度炎症、内皮功能障碍、端粒功能障碍、表观遗传改变等.中医药研究以中药单体和复方研究较多,主要通过调控TLR4/MyD88/NF-κB、NLRP3/Caspase-1、MAPK/ERK1、TNF-α/NF-κB、PI3K/AKT等信号通路,抑制细胞衰老、抗氧化应激、抗炎等,从而延缓血管老化.系统梳理血管老化相关机制及其在心血管疾病中的作用,以及中医药延缓血管老化的药理研究进展,以期为心血管疾病的预防和诊治提供新思路.
Effects of vascular aging on cardiovascular diseases and the intervention mechanism of Chinese medicine
Vascular aging is an important pathological basis for the aging of various organs and systems in the human body,exerting a significant impact on the occurrence of common cardiovascular diseases such as hypertension,atherosclerosis,myocardial ischemia-reperfusion injury,and coronary heart disease.The pathological mechanisms of vascular aging mainly include cellular aging,oxidative stress,mitochondrial dysfunction,chronic low-grade inflammation,endothelial dysfunction,telomere dysfunction,and epigenetic changes.Research on Chinese medicine focuses more on monomers and compound formulas of Chinese medicines,mainly regulating signaling pathways such as TLR4/MyD88/NF-κB,NLRP3/Caspase-1,MAPK/ERK1,TNF-α/NF-κB,and PI3K/AKT to inhibit cellular aging,oxidative stress,and inflammatory,thereby delaying vascular aging.This article has systematically reviewed the related mechanisms of vascular aging and its role in cardiovascular diseases,as well as the pharmacological research progress of Chinese medicine in delaying vascular aging,aiming to provide new insights for the prevention,diagnosis,and treatment of cardiovascular diseases.

vascular agingagingcardiovascular diseasecellular agingoxidative stressmitochondrial dysfunctionchronic low-grade inflammationendothelial dysfunction

余嗣澳、陈铭、陈聪、廖菁、杨漾、付桔、蒋其成

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湖南中医药大学中医学院,湖南 长沙 410208

湖南中医药大学医学院,湖南 长沙 410208

湖南中医药大学中西医结合学院,湖南 长沙 410208

血管老化 衰老 心血管疾病 细胞衰老 氧化应激 线粒体功能障碍 慢性低度炎症 内皮功能障碍

国家自然科学基金湖南省教育厅科研项目湖南省教育厅科研项目湖南省中医药科研项目湖南省中医药科研项目湖南省卫生健康委科研项目湖南中医药大学科研基金重点项目湖南中医药大学研究生创新课题湖南中医药大学研究生创新课题

8170406522A027423C0172A2023030B20230222022020847422021XJJJ0032022CX602023CX172

2024

10.3969/j.issn.1674-070X.2024.05.027

湖南中医药大学学报
湖南中医药大学

湖南中医药大学学报

CSTPCD
影响因子：1.098
ISSN：1674-070X
年,卷(期)：2024.44(5)
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