Objective To study the extraction process and molding process of Yishen Gujing Nuanqi Patch(YSGJNQP).Methods Using osthole,hydroxy-α-sanshool,hyperoside,and extract yield as evaluation indicators,and extraction time,extraction solvent ratio,and ethanol concentration as factors,the Box-Behnken response surface method was used to optimize the optimal extraction process.Taking the initial adhesion,holding adhesion,peeling strength,and sensory evaluation of the gel patch as indicators,the D-optimal mixture design was used to optimize the optimal molding process for YSGJNQP.Results The optimal extraction process for YSGJNQP was reflux extraction for 120 minutes,with an extraction solvent ratio of 12 and an ethanol concentration of 57％,repeated twice using the same method.The optimal molding process had a mass ratio of 6.00％NP700,0.60％PVP-k90,0.15％glycoxyaluminium,5.76％filler,0.10％EDTA-2Na,21.76％glycerin,0.20％citric acid,and 65.43％total amount of water and medicinal solution.Conclusion The optimized extraction process and gel patch preparation process for YSGJNQP in the study are stable and feasible,providing a reference for further development and utilization of this product.
万方数据
维普
