Research progress in preventing and treating myocardial ischemia-reperfusion injury through regulation of the PI3K/Akt signaling pathway by monomers and compound formulas of Chinese medicines
Reperfusion therapy is a common method for preventing and treating acute myocardial infarction(AMI),but it may induce a series of injuries such as arrhythmia and cardiomyocyte apoptosis in the process of improving blood supply,which is called myocardial ischemia-reperfusion injury(MIRI).Modern Chinese medicine practitioners believe that the basic pathogenesis of MIRI is deficiency in root and excess in manifestation,with qi deficiency and yang deficiency as the main causes of deficiency root,and phlegm-turbidity and blood stasis as the main causes of excess manifestation.The combination of deficiency and excess is commonly seen,and the treatment should focus on reinforcing healthy qi to eliminate pathogenic factors.The PI3K/Akt signaling pathway plays an important role in the survival and functional activities of cardiomyocytes during the prevention and treatment of MIRI.This pathway participates in mediating physiological processes such as cell proliferation,growth,and survival,and can also regulate various pathological processes such as myocardial cell apoptosis,autophagy,oxidative stress,and inflammatory response.This bidirectional regulatory effect coincides with the theory of"reinforcing healthy qi to eliminate pathogenic factors"in Chinese medicine.Based on this,this paper reviews the relationship between Chinese medicine in preventing and treating MIRI and the PI3K/Akt signaling pathway,aiming to provide references for the treatment of MIRI and the development of new drugs.
万方数据
维普
