Research progress on pharmacological mechanism and clinical application of Baihe Dihuang Decoction in treating insomnia with depression and anxiety
The incidence of insomnia with depression and anxiety is increasing year by year,which seriously disturbs people's normal study and life.Insomnia,depression,and anxiety can occur independently or coexist,and they are inseparable at the level of symptomatology and disease.Common factors of insomnia with depression and anxiety include the changes in monoamine neurotransmitters,dysfunction of hypothalamic-pituitary-adrenal(HPA)axis,neuroplasticity impairment,activation of inflammatory factors of immune cells,and decreased synthesis of brain-derived growth factor(BDNF).Chinese medicine believes that the core pathogenesis of this disease is heat stagnation in the liver meridian and yin-blood deficiency,which is related to the three viscera of the heart,kidney,and spleen.The famous classical formula Baihe Dihuang Decoction(BHDHD)has the function of nourishing yin and clearing heat,showing remarkable clinical efficacy in treating insomnia with depression and anxiety.This paper summarizes the research progress of BHDHD in treating insomnia with depression and anxiety in recent years from the aspects of research overview,pharmacological mechanism,and clinical efficacy,which provides new methods for the treatment of insomnia with depression and anxiety,as well as new ideas for modern clinical research and the application of famous classical formulas.
Baihe Dihuang Decoctioninsomniadepressionanxietypharmacologymechanism of action
万方数据
维普
