Mendelian randomization analysis of the causal relationship between kidney disease and osteoporosis based on the theory of kidney governing bones
Objective To explore the causal relationship between kidney disease and osteoporosis(OP)under the Chinese medicine theory of kidney governing bones.Methods Using the Mendelian randomization approach,single nucleotide polymorphisms(SNPs)related to kidney disease were screened as instrumental variables from the genome-wide association study(GWAS)database.Additionally,the fixed-effect inverse variance weighted method and multiple sensitivity analyses were employed to assess the causal relationship between kidney disease and osteoporosis(OP).Results Five kinds of Mendelian randomization analyses revealed that membranous nephropathy(OR=1.000 6,95%CI:1.000 2～1.000 9,P=0.001 0),chronic glomerulonephritis(OR=1.000 8,95%CI:1.000 1～1.001 5,P=0.038 0),diabetic nephropathy(OR=1.001 0,95%CI:1.000 1～1.002 0,P=0.031 6),and elevated serum creatinine(OR=1.0130,95%CI:1.000 0～1.026 0,P=0.050 8)can significantly increase the risk of OP,while an estimated increase in glomerular filtration rate was associated with a lower risk of OP(OR=0.997 0,95%CI:0.995 3～0.998 6,P=0.000 3).Multiple sensitivity analyses confirmed the robustness of the results,with no notable pleiotropy(MR-Egger intercept P＞0.05)or heterogeneity(Cohran's Q test P＞0.05)identified.Conclusion This study confirms a positive causal relationship between kidney disease and OP,supporting the theory of kidney governing bones.Thus,it provides new evidence for the prevention and treatment of kidney disease-related OP.
osteoporosischronic kidney diseasekidney functionMendelian randomizationChinese medicine theory
国家科技期刊平台
NSTL
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