Clinical study on the treatment of acute urticaria with dyspnea by Guizhi Mahuang Geban Decoction combined with Suzi Jiangqi Decoction and ebastine
Objective To explore the effects and mechanism of Guizhi Mahuang Geban Decoction(GZMHGBD)combined with Suzi Jiangqi Decoction(SZJQD)and ebastin in the treatment of acute urticaria with dyspnea.Methods A total of 110 patients with acute urticaria accompanied by dyspnea,admitted to the Dermatology Department of Hengshui Chinese Medicine Hospital from October 2020 to June 2023 were equally randomized into two groups.The control group(n=55)was treated with ebastine and vitamin C,while the observation group(n=55)was treated with GZMHGBD combined with SZJQD in addition to the control group's treatment.Each treatment course lasted seven days,with a total of two courses.Clinical efficacy,as well as the symptom scores related to the severity of skin lesions,visual analogue scale(VAS)scores for dyspnea,allergic reaction indicators[total immunoglobulin E(TIgE),leukotriene(LT),interleukin(IL)-4,IL-35],immune function[complement C3,complement C4,immunoglobulin A(IgA),immunoglobulin G(IgG)]and intestinal flora(lactobacillus,Faecalibacterium prausnitzii,bifidobacterium,and Clostridium leptum)abundance before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 98.18%,which was higher than that of the control group(83.64%)(P<0.05).Compared with before treatment,the symptom scores related to the severity of skin lesions and VAS scores decreased in both groups after treatment(P<0.05),with the observation group showing lower scores than the control group(P<0.05);levels of TIgE,LT,and IL-4 all decreased(P<0.05),with the observation group showing lower levels than the control group(P<0.05);the level of IL-35 of both groups increased,with the observation group showing a higher level than the control group(P<0.05);levels of complement C3,IgA,and IgG all increased(P<0.05),with the observation group showing higher levels than the control group(P<0.05);there was no statistically significant difference in the level of complement C4 before and after treatment(P>0.05).After treatment,levels of lactobacilli,Faecalibacteria prausnitzii,and Clostridium leptum all increased(P<0.05),with the observation group showing higher levels than the control group(P<0.05),while there was no significant difference in the level of bifidobacteria(P>0.05).Conclusion The combination of GZMHGBD,SZJQD,and ebastine shows better efficacy than monotherapy with western medicine alone in treating acute urticaria with dyspnea.It can alleviate allergic reaction,regulate the immune function and intestinal flora,thereby relieving the clinical symptoms of the patients effectively.
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