Effects of Zilong Ointment combined with LED red light on the healing of refractory ulcer wounds,TGF-β,and PDGF
Objective To investigate the effects of Zilong Ointment combined with LED red light on the healing of refractory ulcer wounds and on the transforming growth factor of transforming growth factor-β(TGF-β)and platelet-derived growth factor(PDGF).Methods Forty-eight patients with refractory ulcer wounds admitted to the Second Hospital of Hunan University of Chinese Medicine from January 2022 to January 2023 were divided into control group,LED group,Zilong Ointment group,and Zilong Ointment+LED group according to the random table number method,with 12 patients in each group.Continuous intervention was administered for 28 days.The wound healing rate was calculated and clinical efficacy was compared in each group.The pathological changes of wound tissue of each group were observed by HE staining.The expression level of PDGF protein in each group was determined by immunohistochemistry.The expression level of TGF-β protein in each group was checked by Western blot.Results The clinical effective rate of Zilong Ointment group(100.00％)and Zilong Ointment+LED group(100.00％)was higher than that of LED group(83.33％)and control group(25.00％)(P＜0.05,P＜0.01).Compared with those of the 14th day,the wound healing rate and the protein expression levels of PDGF and TGF-β in the Zilong Ointment group and Zilong Ointment+LED group were significantly increased on the 28th day(P＜0.01).Compared with those of the control group and LED group,the wound healing rate,the protein expression levels of PDGF and TGF-β in Zilong Ointment group and Zilong Ointment+LED group were higher on the 14th and 28th day(P＜0.05,P＜0.01).Compared with those of Zilong Ointment Group,the wound healing rate and TGF-β protein expression level of Zilong Ointment+LED group were significantly elevated on both the 14th and 28th day(P＜0.05,P＜0.01).Conclusion Zilong Ointment combined with LED red light therapy has a good effect on chronic refractory ulcer wounds,which may promote wound capillary and fibroblast proliferation by increasing the protein expression levels of TGF-β and PDGF,thereby accelerating the wound healing.
refractory ulcer woundZilong OintmentLED red lightplatelet-derived growth factortransforming growth factor-β
万方数据
维普
