首页|灯盏细辛防治青光眼的研究进展

灯盏细辛防治青光眼的研究进展

Research progress on the prevention and treatment of glaucoma with Erigerontis Herba

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青光眼是一种与眼内压升高密切相关的眼科疾病,其病理过程导致视神经受损和视力减退.全球范围内,青光眼的患病率持续上升,成为公共卫生领域的重要挑战.尽管现代医学在青光眼防治方面取得了一定进展,但当前治疗手段对于病程的改变尚未达到理想水平.灯盏细辛是一种传统中药,其主要有效成分为灯盏花乙素和总咖啡酸酯,对青光眼的治疗具有潜在价值.现代药理学研究揭示,灯盏细辛通过降低眼压、改善眼部血流和调节免疫反应等途径,改善视网膜微环境、促进视网膜神经节细胞生长并减轻其损伤.探讨灯盏细辛主要成分对青光眼的干预机制,为青光眼的预防和治疗提供科学依据.
Glaucoma is an ophthalmic disease closely associated with elevated intraocular pressure,leading to optic nerve damage and vision loss.The prevalence of glaucoma continues to rise globally,posing a significant challenge to public health.Although modern medicine has made certain progress in the prevention and treatment of glaucoma,current therapeutic approaches have not yet achieved optimal outcomes in altering the disease course.Erigerontis Herba,a traditional Chinese medicine,holds potential therapeutic value for glaucoma,primarily due to its active ingredients,scutellarin and total caffeic acid esters.Modern pharmacological research has revealed that Erigerontis Herba aids in glaucoma treatment by lowering intraocular pressure,improving ocular blood flow,and modulating immune responses.These mechanisms contribute to the enhancement of the retinal microenvironment,protection of retinal ganglion cell growth,and reduction of their damage.This paper aims to explore the mechanisms by which the major components of Erigerontis Herba intervene in glaucoma,providing a scientific basis for its prevention and treatment.

glaucomaErigerontis Herbaintraocular pressureretinal microenvironmentapplication of Chinese medicinesmechanism of action

伍紫炫、彭俊、江冰、黄建三、彭清华

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湖南中医药大学,湖南 长沙 410208

湖南中医药大学第一附属医院,湖南 长沙 410007

中南大学湘雅二医院,湖南长沙 410006

湖南湘雅制药股份有限公司,湖南长沙 410013

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青光眼 灯盏细辛 眼压 视网膜微环境 中药应用 作用机制

国家自然科学基金面上项目国家自然科学基金面上项目湖南中医药大学揭榜挂帅科研项目湖南省中医药科研计划项目

82274588818744922022XJJB003D2022045

2024

10.3969/j.issn.1674-070X.2024.09.025

湖南中医药大学学报
湖南中医药大学

湖南中医药大学学报

CSTPCD
影响因子：1.098
ISSN：1674-070X
年,卷(期)：2024.44(9)
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