Effects of Shentong Zhuyu Decoction combined with conventional treatment on nucleus pulposus reabsorption in patients with ruptured lumbar disc herniation
Objective To investigate the effects of Shentong Zhuyu Decoction(STZYD)combined with conventional treatment on nucleus pulposus reabsorption in patients with ruptured lumbar disc herniation(LDH)of blood stasis pattern.Methods A total of 66 patients with ruptured LDH of blood stasis pattern who presented the Second Hospital of Hunan University of Chinese Medicine from December 2022 to December 2023 were divided into control group and treatment group according to the random number table method,with 33 patients in each group.The control group received conventional treatment,while the treatment group was treated with STZYD in addition to the treatment of the control group.Both groups were treated for two weeks.Comparisons were made between the two groups in terms of herniated nucleus pulposus volume and reabsorption rate,Japanese Orthopaedic Association(JOA)score,expression levels of immune inflammatory factors such as interleukin-1 β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α),Chinese medicine(CM)pattern scores,clinical efficacy,and adverse events.Results Compared with before treatment,both groups showed significant reductions in the herniated nucleus pulposus volume,serum levels of IL-1 β,IL-6,and TNF-α,as well as CM pattern scores after treatment(P＜0.05),with the treatment group demonstrating lower values than the control group(P＜0.05).Additionally,there were significant increases in the herniated nucleus pulposus reabsorption rate,JOA scores,and clinical efficacy after treatment(P＜0.05),with the treatment group showing higher values than the control group(P＜0.05).Conclusion STZYD combined with conventional treatment can promote the reabsorption of herniated nucleus pulposus in patients with ruptured LDH of blood stasis pattern,improve the lumbar function and CM pattern scores,reduce immune inflammatory responses,and enhance patients'quality of life.
万方数据
维普
