Effects of modified Huoxue Huayu Decoction combined with tacrolimus on immune factors and renal function in patients with Henoch-Schonlein purpura nephritis
Objective To investigate the effects of modified Huoxue Huayu Decoction(HXHYD)combined with tacrolimus on immune factors and renal function in patients with Henoch-Schonlein purpura(HSP)nephritis of wind-heat and stasis pattern.Methods A total of 94 patients diagnosed with HSP nephritis of wind-heat and stasis pattern admitted to the Nephrology Department of Shijiazhuang Hospital of Traditional Chinese Medicine from January 2023 to February 2024 were selected and divided into control group and observation group by the random number table method,with 47 cases in each group.The control group received tacrolimus 0.05 mg/(kg·d)orally 1 h before meals,twice a day with a 12-h interval;the observation group was treated with modified HXHYD in addition to the treatment of control group,twice a day.Both groups were treated continuously for eight weeks.The clinical efficacy,Chinese medicine(CM)pattern scores,levels of immune factors,renal function,coagulation function,and adverse reactions were compared between the two groups.Results There were no significant differences in the CM pattern scores,levels of immune factors,renal function,and coagulation function between the two groups before treatment(P＞0.05).After treatment,the scores for symptoms such as fever and thirst,edema,hematuria,cutaneous purpura,abdominal pain,slight aversion to wind and cold,as well as the CM pattern total score decreased in both groups.The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),T lymphocyte differentiation antigen molecule 8+(CD8+),red blood cell count(RBC),cystatin C(CysC),urea nitrogen(BUN),24 h urinary protein quantification(24hUP),β2-microglobulin(β2-MG),serum creatinine(SCr),platelet count(PLT),and fibrinogen(FIB)were lower in both groups compared with those before treatment(P＜0.05),while the levels of immunoglobulin G(IgG),T lymphocyte differentiation antigen molecules 4+(CD4+),CD4+/CD8+,thrombin time(TT),activated partial thromboplastin time(APTT),and prothrombin time(PT)were higher(P＜0.05).After treatment,compared with the control group,the CM pattern scores and levels of IgA,IgM,CD8+,RBC,24hUP,β2-MG,CysC,SCr,BUN,PLT,and FIB in the observation group were lower(P＜0.05),while the total clinical effective rate and levels of IgG,CD4+,CD4+/CD8+,TT,APTT,and PT were higher(P＜0.05).Additionally,the observation group exhibited a reduction in the incidence of infection,dizziness,nausea,and gastrointestinal symptoms(P＜0.05).Conclusion The treatment with modified HXHYD combined with tacrolimus for the HSP nephritis of wind-heat and stasis pattern can enhance the clinical efficacy,and improve the immune function,coagulation function,and renal function of patients.
tacrolimusHenoch-Schonlein purpura nephritisHuoxue Huayu Decoctionrenal functionclinical efficacyimmune functioncoagulation function
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