Effects of eight methods of sacred tortoise combined with wrist-ankle acupuncture on chemotherapy-induced nausea and vomiting in patients with stage ⅢB and IV non-small cell lung carcinoma
Objective To investigate the effects of eight methods of sacred tortoise(an acupoint-selecting method according to time)combined with wrist-ankle acupuncture on chemotherapy-induced nausea and vomiting(CINV)in patients with stage ⅢB and Ⅳ non-small cell lung carcinoma(NSCLC).Methods A total of 190 patients with stage ⅢB and Ⅳ NSCLC who were admitted to Qingdao Hospital of Traditional Chinese Medicine from October 2021 to December 2022 were selected as the study subjects,and were divided into the observation group and control group according to the random number table method,with 95 cases in each group.After the propensity score matching,40 cases were included in each group.The occurrence of CINV on the 1st and 4th days after chemotherapy,as well as the quality of life scores before and after chemotherapy between the two patient groups were compared;a comparative analysis of changes in motilin(MTL),gastrin(GAS),and vasoactive intestinal peptide(VIP)levels before and on the 1st,3rd,and 5th days after chemotherapy between the two groups were conducted;the generalized estimating equation was used to evaluate the changes of gastrointestinal hormone levels in the two groups before and after treatment.Results On the 1st day after chemotherapy,there were no statistically significant differences in the incidence,severity and frequency of nausea and vomiting between the two groups(P＞0.05);on the 4th day after chemotherapy,the incidence,severity and frequency of nausea and vomiting in the observation group were lower than those in the control group(P＜0.05).Before chemotherapy,there were no statistically significant differences in quality of life scores between the two groups(P＞0.05);after chemotherapy,the observation group scored higher than the control group in physical condition,physical activity,emotional status,lung cancer-related symptoms,and total score(P＜0.05).There were no statistically significant differences in the levels of MTL,GAS,and VIP between the two groups before chemotherapy and on the 1st day after chemotherapy(P＞0.05);on the 3rd and 5th days after chemotherapy,the MTL level in the observation group was higher than that in the control group,while the VIP level was lower than that in the control group(P＜0.05);on the 3rd day after chemotherapy,the GAS level in the observation group was lower than that in the control group(P＜0.05).The changes of MTL,GAS and VIP levels in the two groups before and after treatment were statistically significant(P＜0.05).Conclusion Eight methods of sacred tortoise combined with wrist-ankle acupuncture has good therapeutic effects on CINV in patients with stage ⅢB and Ⅳ NSCLC.Moreover,it can elevate MTL level,reduce GAS and VIP levels,and thus regulate gastr-ointestinal hormonal balance,holding great significance in cancer treatment.
eight methods of sacred tortoisewrist-ankle acupuncturenon-small cell lung carcinomanausea and vom-itingmotilingastrinquality of life
万方数据
维普
