Atherosclerosis(AS)is the pathological basis of cardiovascular diseases including chronic heart failure and coronary heart disease,which involves pathological mechanisms such as macrophage inflammation and foam cell formation.The incidence rate is increasing year by year,with a notable trend towards affecting younger individuals.The efficacy of Chinese medicine in treating AS is well-established,with high safety and distinctive features.Based on the holistic concept of Chinese medicine and the"heart-spleen-kidney integrated view",Professor HU Zhixi believes that the conditions of heart,spleen,and kidney are closely related to the onset of AS.It is pointed out that,as to the pathogenesis of AS,the deficiency of spleen and kidney is the basis,the intermingled phlegm and stasis is the key,and deficiency in the root while excess in the manifestation is the core.In accordance,the treatment principles are reinforcing healthy qi to eliminate pathogenic factors,and treating both the root and manifestation.The treatment methods involve supplementing the spleen and kidney,and eliminating stasis and resolving phlegm,that is,supplementing deficient qi in the zang-fu organs and removing the pathological products in the blood vessels.Guided by the theory of Chinese medicine and combined with modern medical research,the article briefly reviews the mechanism of action and pathway targets of the compound formulas,Chinese patent medicines,Chinese medicines and their pharmacological components in the treatment of AS in order to provide theoretical basis and new ideas for the treatment of AS in Chinese medicine.
关键词
心-脾-肾一体观/动脉粥样硬化/脾肾亏虚/痰瘀互结/抗炎
Key words
heart-spleen-kidney integrated view/atherosclerosis/spleen and kidney deficiency/intermingled phlegm and stasis/anti-inflammation
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