Observation on the clinical efficacy of acupuncture combined with conventional Western medicine treatment in reducing ICU postoperative delirium
Objective To observe the clinical efficacy of acupuncture combined with conventional Western medicine treatment on postoperative delirium(POD)in ICU patients.Methods Sixty patients who underwent general anesthesia with tracheal intubation followed by ICU treatment at the Second Integrated Chinese and Western Medicine Hospital Affiliated to Hunan University of Chinese Medicine from January 2021 to June 2022 were selected as the study subjects and were divided into control group and observation group by the random number table method,with 30 patients in each group.The control group received conventional Western medicine treatment,while the observation group was additionally treated with acupuncture at specific acupoints,including Baihui(GV 20),Yintang(EX-HN 3),Shuigou(GV 26),Shenting(GV 24),Sishencong(EX-HN 1),Zhongji(CV 3),Houxi(SI 3),Shenmen(HT 7),and Neiguan(PC 6),which lasted for 30 min each time for three consecutive days.The incidence of POD,dosage of analgesic and sedative drugs,levels of central nervous system specific protein(S100-β),neuron-specific enolase(NSE),dopamine(DA),and prostaglandin E2(PGE2)in serum were compared between the two groups,and adverse reactions during treatment were recorded.Results The incidence of POD was 3.33％in the observation group,which was lower than 26.67％in the control group(P＜0.05).Within the observation group,the drug dosage was lower than that before acupuncture treatment(P＜0.05).After treatment,the drug dosage,levels of S100-β,NSE,DA,and PGE2 in the observation group were lower than those in the control group(P＜0.05).No obvious unidentified reactions were observed in either group.Conclusion Acupuncture combined with conventional Western medicine treatment can reduce the incidence of POD and the dosage of analgesic and sedative drugs in ICU patients.The mechanism may be related to reducing central excitability and brain injury,as well as regulating pain transmitters.
ICU postoperative deliriumacupunctureanalgesia and sedationcentral nervous system specific proteinneuron-specific enolasedopamineprostaglandin E2
万方数据
维普
